Recombinant Human IL15&IL15RA Protein, Agonist of Interleukin-15 receptor, CAS No.Ab175449, Agonist of Interleukin-15 receptor

CAS: Ab175449 Cat. No.: rp175449

GRADE & PURITY Animal Free, Carrier Free, Bioactive, ActiBioPure™, High Performance, Fc tag, ≥95%(SDS-PAGE)

Accession #

P40933,Q13261

Protein Tag

C-hFc

Expression system

HEK293

Endotoxin Concentration

<0.1 EU/μg

Bioactivity

Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.

Specifications

Product Name

Recombinant Human IL15&IL15RA Protein, Agonist of Interleukin-15 receptor, CAS No.Ab175449

Synonyms

ALT-803 | IL-15 N72D:IL-15RαSu/Fc | IL-15SA | N-803 | IL-15 Receptor alpha & IL-15 Fusion Protein | IL15RA&IL15 | IL15RA&IL15 Complex | IL 15 | IL-15 | IL15 | IL15_HUMAN | Interleukin 15 | Interleukin-15 | Interleukin15 | MGC9721 | AA690181 | CD215 | I15R

Grade

ActiBioPure™, Animal Free, Bioactive, Carrier Free, Fc tag, High Performance

Specifications & Purity

Animal Free, Carrier Free, Bioactive, ActiBioPure™, High Performance, Fc tag, ≥95%(SDS-PAGE)

Biochemical and Physiological Mechanisms

IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL

Bioactivity

Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.

Endotoxin Concentration

<0.1 EU/μg

Amino Acids

31-96 aa & 49-162 aa (N120D)

Sequence

ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDGGGSGGGSGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Accession #

P40933, Q13261

Predicted molecular weight

47.9 kDa

SDS-PAGE

48 kDa, under reducing conditions.

Action Type

AGONIST

Mechanism of action

Agonist of Interleukin-15 receptor

CAS

Ab175449

Molecule Type

Protein

Storage and Shipping

Reconstitution

Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.

Storage

Store at -20°C,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at -20~-80℃ for more than 1 year. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Protein Bioactivity: Recombinant Human IL15&IL15RA Protein (rp175449)

Recombinant Human IL15&IL15RA Protein (rp175449) - Protein Bioactivity
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED₅₀ for this effect is 9.3 ng/mL.

SDS-PAGE: Recombinant Human IL15&IL15RA Protein (rp175449)

Recombinant Human IL15&IL15RA Protein (rp175449) - SDS-PAGE
2 μg/lane of Recombinant Human IL15&IL15RA Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 50 - 60 kDa under reducing conditions and 120 - 130 kDa under non-reducing conditions.

Associated Targets(Human)

IL2RB Tclin Interleukin-2 receptor subunit beta (0 Activities)

Discover Target: IL2RB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL15RA Tbio Interleukin-15 receptor subunit alpha (0 Activities)

Discover Target: IL15RA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL2RG Tclin Cytokine receptor common subunit gamma (0 Activities)

Discover Target: IL2RG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IL2RB Tclin Interleukin-2 receptor beta chain (1 Activities)

Discover Target: IL2RB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IL2RG Tclin IL-2R beta/gamma (0 Activities)

Discover Target: IL2RG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Genetic information

• Alternate Names: ALT-803 | IL-15 N72D:IL-15RαSu/Fc | IL-15SA | N-803 | IL-15 Receptor alpha & IL-15 Fusion Protein | IL15RA&IL15 | IL15RA&IL15 Complex | IL 15 | IL-15 | IL15 | IL15_HUMAN | Interleukin 15 | Interleukin-15 | Interleukin15 | MGC9721 | AA690181 | CD215 | I15R
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