Risedronate Sodium - ≥98% , Farnesyl diphosphate synthase inhibitor, CAS No.115436-72-1, Farnesyl diphosphate synthase inhibitor

CAS: 115436-72-1 Cat. No.: R129954 Molecular Weight: 305.09 EC Number: 601-362-8 PubChem CID: 4194514

GRADE & PURITY ≥98%

Synonyms

AC-20120 | Acrel | D00942 | H11438 | Sodium trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate | DRFDPXKCEWYIAW-UHFFFAOYSA-M | Risedronate (sodium) | Risedronate sodium 2.5-hydrate, European Pharmacopoeia (EP) Reference Standard | Risedronate so

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Risedronate Sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.
A pyridinyl biphosphonate.

Specifications

Synonyms

AC-20120 | Acrel | D00942 | H11438 | Sodium trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate | DRFDPXKCEWYIAW-UHFFFAOYSA-M | Risedronate (sodium) | Risedronate sodium 2.5-hydrate, European Pharmacopoeia (EP) Reference Standard | Risedronate so

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption. Risedronate sodium is an inhibitor of FDPS.Osteoclast-mediated bone resorption inhibitor. Promotes osteoblast differentiation and reduces osteocyte apoptos

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Farnesyl diphosphate synthase inhibitor

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504762908
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504762908
• Canonical Smiles: C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
• IUPAC Name: sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate
• InChIKey: DRFDPXKCEWYIAW-UHFFFAOYSA-M
• INCHI: 1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
• Isomeric SMILES: C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
• WGK Germany: 3
• RTECS: SZ8567200
• Alternate CAS: 105462-24-6，329003-65-8
• PubChem CID: 4194514
• Molecular Weight: 305.09

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic phosphonic acids and derivatives
      • Subclass Bisphosphonates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic phosphonic acids and derivatives
• Subclass: Bisphosphonates
• Intermediate Tree Nodes: Not available
• Direct Parent: Bisphosphonates
• Alternative Parents: Pyridines and derivatives Organic phosphonic acids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organonitrogen compounds Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Bisphosphonate - Pyridine - Organophosphonic acid - Heteroaromatic compound - Organoheterocyclic compound - Organic alkali metal salt - Azacycle - Organic nitrogen compound - Organic sodium salt - Organic salt - Organic zwitterion - Organopnictogen compound - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO Water 2 mg/mL Ethanol；Soluble in water, insoluble in ethanol
• Sensitivity: Moisture and heat sensitive
• Molecular Weight: 305.090 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 304.983 Da
• Monoisotopic Mass: 304.983 Da
• Topological Polar Surface Area: 151.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 375.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Cong Wang, Wenting Liu, Yong Huang, Lin Zheng, Lili Wang, Ruixi Li, Chang Yang.  (2025)  Mitigating gastrointestinal side effects of risedronate sodium: A study on Bletilla striata polysaccharide microneedle patches.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40288506] [10.1016/j.ijpharm.2025.125609]