≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.
| Canonical Smiles | C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl |
|---|---|
| IUPAC Name | (2,4-dichlorophenyl)methyl carbamimidothioate;hydrochloride |
| InChIKey | COMNQRICZGJVLE-UHFFFAOYSA-N |
| INCHI | 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H |
| Isomeric SMILES | C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl |
| PubChem CID | 12526767 |
| Molecular Weight | 271.59 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Halobenzenes |
| Intermediate Tree Nodes | Chlorobenzenes |
| Direct Parent | Dichlorobenzenes |
| Alternative Parents | Aryl chlorides Isothioureas Sulfenyl compounds Carboximidamides Organochlorides Imines Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | 1,3-dichlorobenzene - Aryl halide - Aryl chloride - Isothiourea - Sulfenyl compound - Carboximidamide - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organosulfur compound - Organonitrogen compound - Organochloride - Organohalogen compound - Imine - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2427644 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427645 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427646 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427647 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427648 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427649 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427650 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427651 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427658 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| K2427659 | Certificate of Analysis | Jul 24, 2024 | R338914 |
| Solubility | Soluble in DMSO: >10 mg/mL and Water: >2 mg/mL |
|---|---|
| Sensitivity | Moisture sensitive |
| Molecular Weight | 271.600 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Exact Mass | 269.955 Da |
| Monoisotopic Mass | 269.955 Da |
| Topological Polar Surface Area | 75.200 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 189.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
