≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Targets
RAAS
In vivo
In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy.
| Molecular Weight | 915.98 |
|---|
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2318341 | Certificate of Analysis | Dec 22, 2025 | V413811 |
| B2318339 | Certificate of Analysis | Dec 22, 2025 | V413811 |
| B2318338 | Certificate of Analysis | Dec 22, 2025 | V413811 |
| B2318336 | Certificate of Analysis | Dec 22, 2025 | V413811 |
| D2419033 | Certificate of Analysis | Apr 07, 2024 | V413811 |
| D2419034 | Certificate of Analysis | Apr 07, 2024 | V413811 |
| F2523352 | Certificate of Analysis | Apr 07, 2024 | V413811 |
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL warmed with 50ºC Water: bath (109.17 mM); Water: 100 mg/mL warmed with 50ºC Water: bath (109.17 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (109.17 mM); |
|---|---|
| Sensitivity | Light sensitive；Moisture Sensitive |
