10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride
IC50& Target:CDK8/CycC 4.4 nM (IC 50 ) CDK19/CycC 10.4 nM (IC 50 ) CDK9/cycT 1070 nM (IC 50 )
In Vitro:SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8. SEL120-34A monohydrochloride w
In Vivo:SEL120-34A monohydrochloride (30, 60mg/kg, p.o. once every day) inhibits growth of AML tumors in a dose-dependent manner in SCID mice after treatment for 17 days. MCE has not independently confirmed the accuracy of these methods. They are for refere
Biological Activity:SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride
| Canonical Smiles | CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl |
|---|---|
| Molecular Weight | 450.6 |
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