Sodium oxamate - 10mM in Water , CAS No.565-73-1

CAS: 565-73-1 Cat. No.: S424787 Summenformel: NH₂COCOONa Molekulargewicht: 111.03 Beilstein Registry Number: 6538153 EG-Nummer: 209-290-5 PubChem CID: 5242

GRADE & PURITY 10mM in Water

Synonyms

Oxamic acid, sodium salt | EINECS 209-290-5 | O 2751 | HY-W013032A | FT-0632400 | MFCD00044553 | NCGC00261598-01 | Oxamic acid sodium salt | Acetic acid, aminooxo-, monosodium salt | AKOS024462579 | EU-0100913 | DTXSID1060342 | Oxamic acid (sodium) | A853

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Sodium oxamate is an inhibitor of gluconeogenesis and glycolysis. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
An inhibitor of gluconeogenesis useful for anticancer research

Specifications

Synonyme

Oxamic acid, sodium salt | EINECS 209-290-5 | O 2751 | HY-W013032A | FT-0632400 | MFCD00044553 | NCGC00261598-01 | Oxamic acid sodium salt | Acetic acid, aminooxo-, monosodium salt | AKOS024462579 | EU-0100913 | DTXSID1060342 | Oxamic acid (sodium) | A853

Spezifikationen & Reinheit

10mM in Water

Biochemische und physiologische Mechanismen

Weak lactate dehydrogenase inhibitor (IC 50 values are 600 and 4400 μM in H460 and A549 cells respectively). Inhibits glycolysis and gluconeogenesis. Pyruvate analog. Decreases extracellular acidification rate.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Kanonisches Lächeln

C(=O)(C(=O)[O-])N.[Na+]

IUPAC Name

sodium;oxamate

InChIKey

RQVZIJIQDCGIKI-UHFFFAOYSA-M

INCHI

1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1

Isomere SMILES

C(=O)(C(=O)[O-])N.[Na+]

PubChem CID

5242

Molekulargewicht

111.03

Beilstein

6538153

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Ebene5 Amino acids and derivatives
          • Ebene6 Alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Alpha amino acids and derivatives
• Alternative Parents: Primary carboxylic acid amides Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Alpha-amino acid or derivatives - Carboxamide group - Carboxylic acid salt - Primary carboxylic acid amide - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Hydrocarbon derivative - Organic sodium salt - Organic salt - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

LDHA Tchem L-lactate dehydrogenase A chain (1573 Activities)

Discover Target: LDHA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MIA PaCa-2 (5949 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 111.030 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 110.993 Da
• Monoisotopic Mass: 110.993 Da
• Topological Polar Surface Area: 83.200 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 90.900
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3