TMI-1 - Moligand™, 10 mM in DMSO , CAS No.287403-39-8

CAS: 287403-39-8 Cat. No.: T1493377 Molecular Weight: 398.49 PubChem CID: 5288615

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) ( IC 50 of 8.4 nM), ADAM-TS-4 , ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors ( TNF-α 、 IL-1β 、 IL-6 ) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC([C@@H]2C(=O)NO)(C)C
• PubChem CID: 5288615
• Molecular Weight: 398.49