trans-4-(Aminomethyl)cyclohexanecarboxylic acid(AMCA) - Moligand™, 10mM in Water , CAS No.1197-18-8

CAS: 1197-18-8 Cat. No.: T420870 Molecular Weight: 157.21 EC Number: 214-818-2

GRADE & PURITY Moligand™, 10mM in Water

Synonyms

tranexamic acid|1197-18-8|trans-4-(Aminomethyl)cyclohexanecarboxylic acid|Cyklokapron|4-(Aminomethyl)cyclohexanecarboxylic acid|701-54-2|Trans AMCHA|Tranexamsaeure|Transamin|1197-17-7|Tranhexamic acid|Cyclocapron|Amstat|trans-Amcha|Rikavarin|Tamcha|Amikap

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Inhibits plasmin-induced fibrinolysis

Specifications

Synonyms

tranexamic acid | 1197-18-8 | trans-4-(Aminomethyl)cyclohexanecarboxylic acid | Cyklokapron | 4-(Aminomethyl)cyclohexanecarboxylic acid | 701-54-2 | Trans AMCHA | Tranexamsaeure | Transamin | 1197-17-7 | Tranhexamic acid | Cyclocapron | Amstat | trans-Amcha | Rikavarin | Tamcha | Amikap

Specifications & Purity

Moligand™, 10mM in Water

Biochemical and Physiological Mechanisms

Antifibrinolytic and plasminogen activation inhibitor. Blocks lysine-binding sites of plasmin and elastase-derived plasminogen fragments (IC 50 = 5 mM).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Canonical Smiles: NC[C@H]1CC[C@@H](CC1)C(O)=O
• IUPAC Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
• InChIKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
• INCHI: 1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
• Isomeric SMILES: C1CC(CCC1CN)C(=O)O
• WGK Germany: 2
• Alternate CAS: 701-54-2
• Molecular Weight: 157.21
• Reaxy-Rn: 2207452
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2207452&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Amino acids
• Alternative Parents: Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Aliphatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as amino acids. These are organic compounds that contain at least one carboxyl group and one amino group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PLG Tclin Plasminogen (0 Activities)

Discover Target: PLG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Molecular Weight: 157.210 g/mol
• XLogP3: -2.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 157.11 Da
• Monoisotopic Mass: 157.11 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 139.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Qiao Yu, Baihai Su, Weifeng Zhao, Changsheng Zhao.  (2022)  Janus Self-Propelled Chitosan-Based Hydrogel Spheres for Rapid Bleeding Control.  Advanced Science,  10  (5): (2205989).  [PMID:36567271] [10.1002/advs.202205989]

2. Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai.  (2022)  Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes.  Bioactive Materials,      [PMID:35415282] [10.1016/j.bioactmat.2022.01.002]

3. Guangxue Chen, Xiaoyuan Guan, Ruixin Xu, Junfei Tian, Fachuang Lu, Minghui He, Jianwen Yang.  (2016)  Thioxanthone dicarboxamide derivatives as one-component photoinitiators for near-UV and visible LED (365–405 nm) induced photopolymerizations.  RSC Advances,  6  (80): (77093-77099).  [PMID:] [10.1039/C6RA13512A]

4. Tao Peng, Xu Lu, Yang Jin, Xicheng Yang, Qian Liu, Chen Chen, Wanting Zhou, Yuting Guo, Yu Zhang, Yankun Gao, Hongjuan Zhang, Hongliang He, Lina Chen.  (2025)  One-stone-four-birds strategy to construct magnetic mesoporous nano-ratio fluorescence sensor for efficient discovery of PSD95-nNOS uncouplers.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.161330]

5. Lin-Xia Liu, Zhi-Kai Liao, Bing-Qi Dong, Shan Jiang, Tie-Chi Lei.  (2024)  Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells.  Annals of Dermatology,      [PMID:38816976] [10.5021/ad.23.108]

6. Yujie Hu, Feiyang Zhang, Jianfeng Zhou, Yi Yang, Deyi Ding, Mingzhang Li, Changming Wang, Boyong Wang, Jinlong Yu, Feng Jiang, Deng-Guang Yu, Hao Shen.  (2025)  Electrospun Tri-Layer Core-Sheath Nanofibrous Coating for Sequential Treatment of Postoperative Complications in Orthopedic Implants.  Small,      [PMID:40898688] [10.1002/smll.202505523]

7. Zizhen Bao, Xiao Ouyang, Yi Liu, Gaoyang Gou, Xiaokang Yao, Yue Zhao, Hang Yin, Yuge Zhang, Shuanma Yan, Zhihua Sun, Zhongfu An, Linyue Liu, Wei Huang, Xiaoping Ouyang.  (2026)  Bright 2D Polar Perovskite Scintillator with Ultrafast Decay by Suppressing Free Carrier Recombination.  ADVANCED MATERIALS,      [PMID:41631384] [10.1002/adma.202517639]