Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 15 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome . Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
| Isomeric SMILES | C[N+](C)(C)[O-] |
|---|---|
| WGK Germany | 3 |
| PubChem CID | 1145 |
| Molecular Weight | 75.11 |
| Reaxy-Rn | 1734787 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 220-222°C |
|---|
| 1. Wang Qiqi, Sun Yue, Zhou Tianyu, Jiang Cong, A Lan, Xu Wenzhou. (2023) Gut microbiota-dependent trimethylamine n-oxide pathway contributes to the bidirectional relationship between intestinal inflammation and periodontitis. Frontiers in Cellular and Infection Microbiology, [PMID:36710972] [10.3389/fcimb.2022.1125463] |
| 2. Chunxia Shi, Maohua Pei, Yao Wang, Qian Chen, Pan Cao, Luyi Zhang, Jin Guo, Wei Deng, Luwen Wang, Xun Li, Zuojiong Gong. (2022) Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:35065293] [10.1016/j.bbrc.2022.01.060] |
| 3. Yadi Liu, Guoxiao Lai, Yinrui Guo, Xiaocui Tang, Ou Shuai, Yizhen Xie, Qingping Wu, Diling Chen, Xujiang Yuan. (2021) Protective effect of Ganoderma lucidum spore extract in trimethylamine-N-oxide-induced cardiac dysfunction in rats. JOURNAL OF FOOD SCIENCE, 86 (2): (546-562). [PMID:33438268] [10.1111/1750-3841.15575] |
| 4. Cao Ting, Wang Xue-lian, Rao Jiang-yan, Zhu Hui-feng, Qi Hong-yi, Tian Zhen. (2024) Periplaneta americana L. extract exerts neuroprotective effects by inhibiting endoplasmic reticulum stress via AKT-dependent pathway in experimental models of Parkinson’s disease. Chinese Medicine, 19 (1): (1-24). [PMID:39538357] [10.1186/s13020-024-01029-2] |
| 5. wenwen Li, Zeyuan Deng, Shuang Xiao, qian Du, Mengru Zhang, Hailing Song, Caidong Zhao, Liufeng Zheng. (2024) Protective effect of vitexin against high fat-induced vascular endothelial inflammation through inhibiting trimethylamine N-oxide-mediated RNA m6A modification. Food & Function, [PMID:38855818] [10.1039/D3FO04743A] |
| 6. Jun Zhang, Xiu-tian-feng E, Bo Yang, Xiumei Ma, Xueping Wang, Ninghui Chang, Qiuyu Zhang, Ji-Jun Zou, Junjian Xie. (2024) Synthesis of Highly Strained Cyclobutane Fuels via Room-Temperature-Integrated Oxidation/[2 + 2] Cycloaddition of Lignocellulose-Based Cyclic Ketones and Cyclic Alcohols. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.4c04927] |
| 7. Zhang Ning, Liu Liangju, Lv Xiaowang, Wang Yixuan, Zhang Wei, Wen Xin, Yu Fan, Zhou Tingting. (2024) TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells. Journal of Cardiovascular Translational Research, [PMID:38980653] [10.1007/s12265-024-10543-5] |
| 8. Qian Chen, Huaxing Zhang, Yuhong Chen, Yangxuan Peng, Yuhan Yao, Hongmei Xue, Qi Guo, Danyang Tian, Lin Xiao, Xu Teng, Mingqi Zheng, Bing Xiao, Yuming Wu, Sheng Jin. (2025) Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction. LIFE SCIENCES, [PMID:40074144] [10.1016/j.lfs.2025.123554] |
| 9. D Shao, L Bai, Q Chen, Y Chen, Z Qiu, Y Liu, S Jin, Y Wu, J Dai. (2025) Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis. PHYSIOLOGICAL RESEARCH, [PMID:40886370] [PMID:40886370] |
| 10. Likun Wang, Xuhui Yu, Xiaoyue Hao, Qingyin Di, Lukai Shen, Donghui Li. (2025) Nanostructure modification and enhanced photoluminescence of In3+ doped WO3-x synthesized by solvothermal method. JOURNAL OF ALLOYS AND COMPOUNDS, [PMID:] [10.1016/j.jallcom.2025.184683] |
| 11. Hailing Song, Yun Ma, qian Du, Zeyuan Deng, Yalun Zou, Yadong Miao, Jing Li, Liufeng Zheng. (2025) Flaxseed cyclolinopeptide-mediated regulation of α-linolenic acid metabolism alleviates high-fat diet-induced vascular inflammation. Food & Function, [PMID:41489921] [10.1039/D5FO02406D] |
| 12. Decui SHAO, Lu BAI, Qian CHEN, Yuhong CHEN, Zhaoxu QIU, Yinuo LIU, Sheng JIN, Yuming WU, Jing DAI. (2025) Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis. PHYSIOLOGICAL RESEARCH, 74 (3): (613). [PMID:40886370] [10.33549/physiolres.935576] |
| 13. Q Chen, Z Qiu, Y Zhao, L Bai, Y Chan, S Jin, F Ma, J Dai. (2026) TMAO Induced Kidney Aging by Activating ZBP1-Mediated Necroptosis. PHYSIOLOGICAL RESEARCH, [PMID:41811704] [PMID:41811704] |
| 14. Wu Xinya, Pang Chunlin, Li Qikai, Huang Yu-Ting, Wang Sijia, Cheng Chun, Li Wei, He Chuan, Deng Qiyu, Zhu Hengjia, Ni Meng, Chi Yun, Wang Liqiu, Feng Shien-Ping. (2026) In-situ recomposition of polyethyleneimine additive enables a multiprocess long-lifetime thermocell. Nature Communications, [PMID:] [10.1038/s41467-026-70392-5] |
| 15. Tao Ye, Xuandong Kong, Xinhuang Lv, Qiyao Li, Hangqi Jin, Mozi Chen, Jiaming Liu, Ming Zhao. (2026) Microbial Metabolite Trimethylamine N-Oxide Exacerbated Microglial-Mediated Neuroinflammation in Hemorrhagic Stroke. Journal of Stroke & Cerebrovascular Diseases, [PMID:41786258] [10.1016/j.jstrokecerebrovasdis.2026.108603] |
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