Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex - ≥95% , CAS No.36309-88-3

CAS: 36309-88-3 Cat. No.: T109758 Molecular Weight: 1169.17 PubChem CID: 11980975

GRADE & PURITY ≥95%

Synonyms

tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(ii) dichloride | 4,7-diphenyl-1,10-phenanthroline;ruthenium(2+);dichloride | Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium dichloride | tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(ii)dichloride

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Ru(ddp)) is a widely used probe for luminescent detection and quantitation of oxygen. The fluorescence of the dye (abs. λmax 455 nm, luminescence λmax 613 nm) is strongly reduced by molecular oxygen due to dynamic quenching, making Ru(dpp) a viable oxygen probe based on either measurement of intensity or decay time. Ru(ddp) has been used for fiber optic sensors, studies on oxygen in skin and skin tumors, measurement of oxygen flux through skin, and for oxygen imaging.
Ruthenium-tris(4,7-diphen?yl-1,10-phenanthroline) dichloride (Ru(dpp)) has been widely used as a probe for luminescent detection and quantitation of oxygen. The fluorescence of the dye (abs. λmax 455 nm, luminescence λmax 613 nm) is strongly reduced by molecular oxygen due to dynamic quenching, making Ru(dpp) a viable oxygen probe based on either measurement of intensity or decay time. Ru(ddp) has been used for fiber optic sensors, studies on oxygen in skin and skin tumors, measurement of oxygen flux through skin, and for oxygen imaging

Specifications

Synonyms

tris(4, 7-diphenyl-1, 10-phenanthroline)ruthenium(ii) dichloride | 4, 7-diphenyl-1, 10-phenanthroline;ruthenium(2+);dichloride | Tris(4, 7-diphenyl-1, 10-phenanthroline)ruthenium dichloride | tris(4, 7-diphenyl-1, 10-phenanthroline)ruthenium(ii)dichloride

Specifications & Purity

≥95%

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 488197828
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488197828
• Canonical Smiles: C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5.C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5.C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5.[Cl-].[Cl-].[Ru+2]
• IUPAC Name: 4,7-diphenyl-1,10-phenanthroline;ruthenium(2+);dichloride
• InChIKey: SKZWFYFFTOHWQP-UHFFFAOYSA-L
• INCHI: 1S/3C24H16N2.2ClH.Ru/c3*1-3-7-17(8-4-1)19-13-15-25-23-21(19)11-12-22-20(14-16-26-24(22)23)18-9-5-2-6-10-18;;;/h3*1-16H;2*1H;/q;;;;;+2/p-2
• Isomeric SMILES: C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5.C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5.C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5.[Cl-].[Cl-].[Ru+2]
• WGK Germany: 3
• PubChem CID: 11980975
• Molecular Weight: 1169.17

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Phenylquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Phenylquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylquinolines
• Alternative Parents: Phenanthrolines Phenylpyridines Benzene and substituted derivatives Heteroaromatic compounds Organic transition metal salts Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Phenylquinoline - 1,10-phenanthroline - 4-phenylpyridine - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic metal salt - Organic transition metal salt - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in DMF, chloroform, ethanol, methanol, tolueme (moderately), glycol, and acetone. Insoluble in water.
• Sensitivity: light sensitive,Moisture sensitive
• Molecular Weight: 1169.200 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 1168.24 Da
• Monoisotopic Mass: 1168.24 Da
• Topological Polar Surface Area: 77.300 Ų
• Heavy Atom Count: 81
• Formal Charge: 0
• Complexity: 409.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 6

XLogP3

References

1. Qiong Yao, Yi-Zhuo Qian, Ji Xia, Shui-dong Xiong, Qi Wang.  (2023)  Dissolved oxygen sensor based upon quenching of single optical path fluorescence intensity.  INSTRUMENTATION SCIENCE & TECHNOLOGY,      [PMID:] [10.1080/10739149.2023.2293981]

2. Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai.  (2023)  Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation.  Asian Journal of Pharmaceutical Sciences,      [PMID:37915760] [10.1016/j.ajps.2023.100851]

3. Zhaoyang Guo, Yujia Xin, Lan Yang, Ruixue Ran, Guoyun Wan, Aijing Ma, Hongying Ren, Yinsong Wang, Xiaoying Yang.  (2022)  Biomimetic nanotherapeutics based on oxygen supply and ultrasmall Cu-Se-Au alloy nanoparticles for boosting radio-photothermal ablation of breast cancer.  Nano Today,      [PMID:] [10.1016/j.nantod.2022.101587]

4. Zhentao Zhang, Haiqing Zhong, Yi Zhou, Peng Ke, Qi Dai, Yiying Lu, Xincheng Zhong, Qiyao Yang, Yiyi Xia, Xiaoyan Bao, Linjie Wu, Min Han, Jianqing Gao.  (2022)  Lactate-driving Pt nanoflower with positive chemotaxis for deep intratumoral penetration.  Nano Today,      [PMID:] [10.1016/j.nantod.2022.101542]

5. Xiao Zheng, Ying Liu, Yiqiong Liu, Tingting Zhang, Yuge Zhao, Jie Zang, Yan Yang, Ruiqing He, Gaowei Chong, Shuangrong Ruan, Dailin Xu, Yongyong Li, Haiqing Dong.  (2022)  Dual Closed-Loop of Catalyzed Lactate Depletion and Immune Response to Potentiate Photothermal Immunotherapy.  ACS Applied Materials & Interfaces,      [PMID:35578899] [10.1021/acsami.2c07254]

6. Jiulong Zhang, Xiaoyan Sun, Lin Liu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao.  (2022)  Tumor-permeated ATP-based size-controllable immunogenic cell death amplifier remodel immunosuppressive microenvironment to boost cancer immunotherapy.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2022.101518]

7. Bo Ling, Yaguang Wang, Ruo Mi, Di Wang, Hongqi Chen, Xiaohu Li, Ye Zhang, Lun Wang.  (2022)  Multimodal Imaging and Synergetic Chemodynamic/Photodynamic Therapy Achieved Using an NaGdF4,Yb,Er@ NaGdF4,Yb,Tm@NaYF4@Fe-MOFs Nanocomposite.  Chemistry-An Asian Journal,  17  (14): (e202200161).  [PMID:35485259] [10.1002/asia.202200161]

8. Yiqiong Liu, Dailin Xu, Ying Liu, Xiao Zheng, Jie Zang, Wanli Ye, Yuge Zhao, Ruiqing He, Shuangrong Ruan, Tingting Zhang, Haiqing Dong, Yan Li, Yongyong Li.  (2022)  Remotely boosting hyaluronidase activity to normalize the hypoxic immunosuppressive tumor microenvironment for photothermal immunotherapy.  BIOMATERIALS,      [PMID:35436740] [10.1016/j.biomaterials.2022.121516]

9. Yang Liu, Xiaoping Zhang, Tengling Wu, Bo Liu, Jianhai Yang, Wenguang Liu.  (2021)  Chinese herb-crosslinked hydrogel bearing rBMSCs-laden polyzwitterion microgels: Self-adaptive manipulation of micromilieu and stemness maintenance for restoring infarcted myocardium.  Nano Today,      [PMID:] [10.1016/j.nantod.2021.101306]

10. Xiudan Wang, Yuling Mao, Changshan Sun, Qinfu Zhao, Yikun Gao, Siling Wang.  (2021)  A versatile gas-generator promoting drug release and oxygen replenishment for amplifying photodynamic-chemotherapy synergetic anti-tumor effects.  BIOMATERIALS,      [PMID:34229242] [10.1016/j.biomaterials.2021.120985]

11. Yajun Ma, Jianquan Chen, Yan Yang, Hanqing Qian.  (2024)  Closed-loop of Catalyzed Lactate Oxidization Synergistically Sensitizes Apoptosis and Ferroptosis for Cancer Therapy.  ChemNanoMat,      [PMID:] [10.1002/cnma.202300611]

12. Yujie Wang, Qianru Zhou, Le Lu, Jianhua Xu, Gang Yang, Xuan Sun, Xue Bao, Lina Kang, Pin Lv, Renyuan Liu, Biao Xu, Qi Yang, Dan Mu, Bing Zhang.  (2025)  Combining oxygen delivery and generation for targeted atherosclerosis therapy.  JOURNAL OF CONTROLLED RELEASE,      [PMID:39983924] [10.1016/j.jconrel.2025.02.053]

13. Yifan Cui, Dezhi Yang, Qiulan Li, Zhongmei Peng, Zitao Zhong, Yuzhu Song, Qinqin Han, Yaling Yang.  (2024)  Cu,Zn,I-Doped Carbon Dots with Boosted Triple Antioxidant Nanozyme Activity for Treatment of DSS-Induced Colitis.  ACS Applied Materials & Interfaces,      [PMID:38860867] [10.1021/acsami.4c03627]

14. Yahui Han, Lin Du, Jinfu Wu, Hongjian Zhang, Guangzhen Yang, Yi Zheng, Chengtie Wu.  (2025)  Diatomaceous cross-species constructs for tendon-to-bone regeneration.  Materials Today,      [PMID:] [10.1016/j.mattod.2024.12.010]

15. Wenyan Yan, Qinle Huang, Lin Zhou, Xingyu Lin.  (2024)  Direct photoelectrochemical detection of ethanol in complex biological sample.  BIOSENSORS & BIOELECTRONICS,      [PMID:39522466] [10.1016/j.bios.2024.116915]

16. Xingchen Li, Ming Hao, Annan Liu, Lei Li, Maja D. Nešić, Bai Yang, Weiwei Liu, Quan Lin.  (2024)  Dual-activity nanozyme as an oxygen pump to alleviate tumor hypoxia and enhance photodynamic/ NIR-II photothermal therapy for sniping oral squamous cell carcinoma.  Acta Biomaterialia,      [PMID:39401597] [10.1016/j.actbio.2024.10.018]

17. Jiawei Bao, Jiayu Mi, Yi Xia, Han Gui, Haixue Jia, Dianyu Wang, Hongjing Luo, Linzhu Su, Jiamin Zhang, Jinjian Liu, Jianfeng Liu.  (2024)  Heme-Mimetic Photosensitizer with Iron-Targeting and Internalizing Properties for Enhancing PDT Activity and Promoting Infected Diabetic Wound Healing.  ACS Applied Bio Materials,      [PMID:38772009] [10.1021/acsabm.4c00427]

18. Guoqin Huang, Lianying Zhang, Jiahao Feng, Dan Wu, Libo Wu, Weilun Pan, Yu Jiang, Ming Chen, Jinxiang Chen, Pixian Shui.  (2025)  Hypoxia-Responsive Covalent Organic Framework Nanoplatform for Breast-Cancer-Targeted Cocktail Immunotherapy via Triple Therapeutic Switch Mechanisms.  Small,      [PMID:39797461] [10.1002/smll.202407553]

19. Jiong Li, Dongqin Lei, Yanbing Cao, Fuli Xin, Zhenxi Zhang, Xiaolong Liu, Ming Wu, Cuiping Yao.  (2024)  Nanozyme Decorated Metal-Organic Framework Nanosheet for Enhanced Photodynamic Therapy Against Hypoxic Tumor.  International Journal of Nanomedicine,      [PMID:39315364] [10.2147/IJN.S466011]

20. Siyuan Luo, Yueyan Yang, Liuting Chen, Perumal Ramesh Kannan, Weili Yang, Yongjia Zhang, Ruibo Zhao, Xiaoli Liu, Yao Li, Xiangdong Kong.  (2024)  Outer Membrane Vesicle-Wrapped Manganese Nanoreactor for Augmenting Cancer Metalloimmunotherapy through Hypoxia Attenuation and Immune Stimulation.  Acta Biomaterialia,      [PMID:38734282] [10.1016/j.actbio.2024.05.010]

21. Wende Fan, Yulin Xie, Yinyuan Zhang, Xiaoju Li, Chunxia Li.  (2024)  PdCu nanoparticles with multienzymatic activity to treat tumors through the synergistic photothermal and chemodynamic therapy.  Materials Research Express,      [PMID:] [10.1088/2053-1591/ad51da]

22. Min You, Yaxin Guo, Hui Yu, Haiyan Yin, Xinlei Shi, Ziqing Tang, Jia Yang, Gang Qin, Jianliang Shen, Qiang Chen.  (2024)  Polyphenol-enhanced wet adhesive hydrogel with synergistic mechanical activation and ROS scavenging for accelerating diabetic wound healing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.157103]

23. Liu Lu, Zhao Xuefen.  (2024)  Preparation of environmentally responsive PDA&DOX@LAC live drug carrier for synergistic tumor therapy.  Scientific Reports,  14  (1): (1-16).  [PMID:38987493] [10.1038/s41598-024-66966-2]

24. Donghui Zhao, Yunhao Deng, Junyi Shi, Xinye Ni, Chaoqing Li, Yang Bai, Yang Xuan, Jianhao Wang.  (2024)  Self-assembling gelatin based delivery of multienzyme activity nanozyme and photosensitizer for ROS storm based cancer therapy.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39033890] [10.1016/j.ijbiomac.2024.133963]

25. Peng Hu, Xiaowen Peng, Shuang Zhao, Fan Li, Guoye Yang, Wujie Guo, Shuling Yu, Jianjun Cheng, Juan Cen, Jiahua Shi.  (2024)  Self-sacrificed construction of versatile nanoadjuvant for synergistically enhanced immunogenic cell death and improved anti-tumor immunity.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.152033]

26. Huan Liu, Sumei Qin, Hongyan Zhang, Zhongyin Chen, Yiwei Zhao, Jia Liu, Yan Deng, Miaodeng Liu, Wei Chen, Zheng Wang, Lin Wang.  (2024)  Silk Sericin-based ROS-Responsive Oxygen Generating Microneedle Platform Promotes Angiogenesis and Decreases Inflammation for Scarless Diabetic Wound Healing.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202404461]

27. Yanling Wang, Lishi Luo, Tuotuo Zhang, Jun-Rui Hu, Huiling Wang, Feng Bao, Chonglu Li, Yao Sun, Junrong Li.  (2024)  Strategically Engineered Ru(II) Complexes with Enhanced ROS Activity Enabling Potent Sonodynamic Effect against Multidrug-Resistant Biofilms.  ACS Applied Materials & Interfaces,      [PMID:39297327] [10.1021/acsami.4c11650]

28. Yi-Shu Li, Lu-Yi Ye, Yan-Xi Luo, Wen-Jie Zheng, Jing-Xing Si, Xue Yang, You-Ni Zhang, Shi-Bing Wang, Hai Zou, Ke-Tao Jin, Tong Ge, Yu Cai, Xiao-Zhou Mou.  (2024)  Tumor-targeted Delivery of Copper-manganese Biomineralized Oncolytic Adenovirus for Colorectal Cancer Immunotherapy.  Acta Biomaterialia,      [PMID:38458511] [10.1016/j.actbio.2024.02.044]

29. Xiaoyang Wu, Shiji Lu, Yusheng Zhang, Kai Wu, Junzhong Jiang, Xiaoyin Liu, Dan Wei, Chengheng Wu, Jie Ding, Liangxue Zhou, Jing Sun, Hongsong Fan.  (2025)  Synergistic Viscoelastic-Oxygenation Strategy in Injectable Granular Hydrogels for Neurovascular Regeneration Post-Ischemic Stroke.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202511902]

30. Shuang Zhao, Xuesong Wang, Ruijia Deng, Xiaoqi Tang, Zuowei Xie, Ping Huang, Xianlan Wu, Jie Luo, Yu Tang, Jing Sheng, Sha Yang, Ming Chen, Kai Chang.  (2025)  A Trinity DNAzyme Circuit with Dual-Confinement Effect for Imaging-Guided Combined Gene/Chemo-Dynamic Therapy.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202422309]

31. Zhang Lian-Ying, Chen Xiao-Tong, Li Rong-Tian, Meng Wei, Huang Guo-Qin, Chen Yong-Jian, Ge Feng-Jun, Zhang Qun, Quan Yu-Jun, Zhang Cai-Tao, Liu Yi-Fei, Chen Ming, Chen Jin-Xiang.  (2025)  Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-22).  [PMID:39910569] [10.1186/s12951-025-03132-4]

32. Shanyi Lin, Hao Liu, Letian Lv, Guanyu Jin, Xinyu Xiang, Bingzheng Yu, Yuanzhen Su, Shucheng Zhang, Zijuan Wang, Zhaofan Yang, Luyao Wang, Linlin Liu, Shixian Lv, Wei Guo, Yu Guo.  (2025)  Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment.  Bioactive Materials,      [PMID:41141582] [10.1016/j.bioactmat.2025.10.001]

33. Haijiao Wang, Ruiling Gou, Jiayu Chen, Qian Wang, Xiaoyu Li, Jiaxin Chang, Hongli Chen, Xianwen Wang, Guoyun Wan.  (2024)  Catalase-positive Staphylococcus epidermidis based cryo-millineedle platform facilitates the photo-immunotherapy against colorectal cancer via hypoxia improvement.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:39047378] [10.1016/j.jcis.2024.07.145]

34. Lixian Huang, Jinzhe Liang, Jiaqi Lu, Min He, Yidong Bin, Yanni Luo, Shulin Zhao, Shengqiang Hu, Liangliang Zhang.  (2025)  A smart nanoprobe with simultaneously triggering reactive oxygen species and NIR-II fluorescence for enhanced chemodynamic/photodynamic therapy and ratiometric imaging- guided tumor resection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.137971]

35. Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song.  (2025)  Targeting Hyperglycemic Bone Pre-Metastatic Niche for Breast Cancer Bone Metastasis Therapy.  Advanced Science,      [PMID:40491413] [10.1002/advs.202504924]

36. Lijie Wang, Zixuan Wang, Jiarong Chang, Zhiyue Zhou, Xihan Wang, Zhaoming Li, Dawei Li, Fang Wang, Wen Zhang, Kannapathirage Dilini Maheshika Gunarathne, Xin Meng.  (2025)  Dual-Strategy Pullulan-Soluble Microneedles Based on LL37@ZIF-8 and Artificial Nanozyme Antioxidation for Infected Wound Healing.  ACS Applied Materials & Interfaces,      [PMID:40524420] [10.1021/acsami.5c07412]

37. Xueyang Wang, Shuhua Liu, Shisuo Jing, Siyu Zhang, Yinli Jin, Wen Zhang, Qiongfang Ruan, Wei Li.  (2025)  Nanozyme-Engineered Probiotic Microneedle Patch for Chronic Diabetic Wound Therapy.  Advanced Science,      [PMID:40959857] [10.1002/advs.202512127]

38. Zhang Yuanfeng, Yang Enguang, Zhang Xinyu, Shi Yibo, Fan Guangrui, Wang Yuhan, Tian Junqiang, Wang Hanzhang, Dong Zhilong, Wang Yingru, Cheng Liang, Zhao Zhiwen, Zhang Yonghai, Wang Baodui, Wang Zhiping.  (2025)  A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (795).  [PMID:41275281] [10.1186/s12951-025-03855-4]

39. Wenjia Liu, Nina Zhang, Xu Guo, Xiaofan Zhang, Ying Wang, Jinchao Zhang, Kun Ge, Guoqiang Zhou.  (2026)  Dual-Pathway Pyroptosis Synergistically Triggered by ZIF-90 and Photothermal Boosting of Multienzyme Activity for Enhanced Breast Cancer Immunotherapy and Lung Metastasis Suppression.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202531598]

40. Dongqiu Li, Bingyi Xu, Feifei Ren, Jiajing Yu, Yan Tong, Shiwu Deng, Hezhong Jiang.  (2026)  Lipase-Activated MnO2 Nanoflowers for Precise Biofilm Imaging and Oxygen-Enhanced Sonodynamic Therapy to Promote Diabetic Wound Healing.  Advanced Healthcare Materials,      [PMID:41636357] [10.1002/adhm.202505333]

41. Lidong Wang, Yongyan Sun, Yuting Sun, Changbin Zhang, Guixi Wang, Junnan He, Yan Zhao, Ming Li.  (2026)  GSH-Activated Cu-TCPP(Zn)/Ti3C2Tx Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma.  ACS Applied Materials & Interfaces,      [PMID:41747263] [10.1021/acsami.6c00090]

42. Shanli Wang, Zejin Ju, Yingwu Wang, Zijie Liu, Xingzhe Wang, Hua Jiao, Minhua Cao, Yude Wang, Wenyan Yin, Yuliang Zhao.  (2026)  Synergizing Pt–O–Mo Coupling and Electron Gradient: A Nanozyme Paradigm for Low-Dose Tumor Radiosensitization.  ACS Nano,      [PMID:] [10.1021/acsnano.6c00367]

43. Hong Jiang, Qin-Xie Xie, Tianzhao Tian, Qingqing Yang, Peipei Qian, Jia-Yi Liu, Wending Yan, Shengfeng Huang, Cui Shao, Wei Yi, Yifa Chen, Xu-Jia Hong.  (2026)  Oxygen-Adaptive Covalent Organic Framework Nanoarchitectonics with High Photothermal Conversion Efficiency for Quadruple-Modal Tumor Therapy.  Advanced Healthcare Materials,      [PMID:] [10.1002/adhm.202504853]