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10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
IC50& Target:IC 50 : 4.9 nM (IP6K2), 8.9 nM (IP6K1), 1320 nM (IP6K3) .
In Vitro:UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP 7 levels by 81% and 5-InsP 8 levels by 63%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:UNC7467 (5mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis. UNC7467 (1-5mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg
Biological Activity:UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
| Canonical Smiles | O=C(C1=CC2=C(ON=C2C=C1)C3=CC=C(C=C3)C4=CC=CC=C4)O |
|---|---|
| Molecular Weight | 315.32 |
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