UNC9994 hydrochloride - ≥98% , CAS No.2108826-33-9

CAS: 2108826-33-9 Cat. No.: U647226 Summenformel: C₂₁H₂₃Cl₃N₂OS Molekulargewicht: 457.84 PubChem CID: 121230971

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D 2 receptor ( D 2 R ) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a K i of 79 nM for D 2 R . UNC9994 hydrochloride is also an antagonist of G i -regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity

In Vitro

UNC9994 hydrochloride induces D 2 -mediated β-arrestin-2 translocation with an EC 50 s of 6.1 nM and 448 nM in Tango assay and DiscoveRx assay, respectively. UNC9994 hydrochloride is an antagonist at 5HT 2A and 5HT 2B and an agonist at 5HT 2C and 5HT 1A. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

UNC9994 (2.0 mg/kg; i.p.; once) hydrochloride shows antipsychotic activity that is attenuated in β-arrestin-2 knockout mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J wild-type and β-arrestin-2 knockout mice Dosage: 2.0 mg/kg, followed 30 min later with 6 mg/kg phencyclidine (PCP, i.p.) Administration: IP, once Result: Markedly inhibited PCP-induced hyperlocomotion in wild-type mice and the activity was completely abolished in β-arrestin-2 knockout mice.

Form:Solid

IC50& Target:D 3 Receptor 17 nM (Ki) D 2 Receptor 79 nM (Ki) D 4 Receptor 138 nM (Ki) D 1 Receptor 4000 nM (Ki) 5-HT 2B Receptor 25 nM (Ki) 5-HT 1A Receptor 26 nM (Ki) 5-HT 2A Receptor 140 nM (Ki) 5-HT 2C Receptor 512 nM (Ki)

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D 2 receptor ( D 2 R ) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a K i of 79 nM for D 2 R . UN

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Namen und Kennungen

• Kanonisches Lächeln: C1CN(CCC1C2=C(C(=CC=C2)Cl)Cl)CCCOC3=CC4=C(C=C3)SC=N4.Cl
• IUPAC Name: 5-[3-[4-(2,3-dichlorophenyl)piperidin-1-yl]propoxy]-1,3-benzothiazole;hydrochloride
• InChIKey: MTDQOQYYKZUEEK-UHFFFAOYSA-N
• INCHI: 1S/C21H22Cl2N2OS.ClH/c22-18-4-1-3-17(21(18)23)15-7-10-25(11-8-15)9-2-12-26-16-5-6-20-19(13-16)24-14-27-20;/h1,3-6,13-15H,2,7-12H2;1H
• PubChem CID: 121230971
• Molekulargewicht: 457.84

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2108826-33-9, the molecular formula is C21H23Cl3N2OS, and the molecular weight is 457.84 g/mol. InChIKey MTDQOQYYKZUEEK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.