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Valemetostat (DS-3201) - Moligand™, ≥98% , Inhibitor of enhancer of zeste 1 polycomb repressive complex 2 subunit;Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit, CAS No.1809336-39-7, Inhibitor of enhancer of zeste 1 polycomb repressive complex 2 subunit;Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

CAS: 1809336-39-7 Cat. No.: V414273 Molecular Weight: 488.02
COA
Valemetostat (DS-3201) - Moligand™, ≥98% CAS No(1809336-39-7) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
SCHEMBL18393626 | (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide | SCHEMBL18639210 | HY-109108 | NSC813381 | NSC-813381 | Valemetostat | 60RD0234VE | M
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
Status
Price
Qty
1mg
V414273-1mg
5

$45.90

$90.90
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5mg
V414273-5mg
3

$131.90

$186.90
Save $55.00 (29.43%)
25mg
V414273-25mg
3

$399.90

$548.90
Save $149.00 (27.15%)
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Valemetostat (DS-3201) Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor.


Targets

EZH1 ; EZH2


In vitro

Valemetostat significantly reducs ATL cell viability compared with the others. Valemetostat significantly reactivates the expression of the highly H3K27me3-accumulated EZH1/2 target genes in an ex vivo culture of primary ATL cells. Valemetostat shows superior anti-growth effects compared with EZH2-selective inhibitor in malignant lymphoma cell lines..


Cell Research(from reference)

Cell lines：23 cell lines derived from hematological malignancies 

Incubation Time：1, 7, 14 days 

Specifications

Synonyms
SCHEMBL18393626 | (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl]-2, 4-dimethyl-1, 3-benzodioxole-5-carboxamide | SCHEMBL18639210 | HY-109108 | NSC813381 | NSC-813381 | Valemetostat | 60RD0234VE | M
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of enhancer of zeste 1 polycomb repressive complex 2 subunit;Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit
Purity
≥98%
Names and Identifiers
Pubchem Sid528767683
Canonical SmilesCC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)OC(O3)(C)C4CCC(CC4)N(C)C)Cl)C
IUPAC Name(2R)-7-chloro-2-[4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide
InChIKeySSDRNUPMYCFXGM-ZZHSESOFSA-N
INCHI1S/C26H34ClN3O4/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32)/t17?,18?,26-/m1/s1
Isomeric SMILES CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)O[C@@](O3)(C)C4CCC(CC4)N(C)C)Cl)C
Molecular Weight 488.02
Reaxy-Rn 37408807
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37408807&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
EZH1 Tchem Histone-lysine N-methyltransferase EZH1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (2012 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EZH1 Tchem Histone-lysine N-methyltransferase EZH1 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
G2524588Certificate of AnalysisFeb 19, 2025 V414273
G2524589Certificate of AnalysisFeb 19, 2025 V414273
G2524590Certificate of AnalysisFeb 19, 2025 V414273
Chemical and Physical Properties
SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL (204.9 mM);    
Molecular Weight488.000 g/mol
XLogP34.400
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass487.224 Da
Monoisotopic Mass487.224 Da
Topological Polar Surface Area79.900 Ų
Heavy Atom Count34
Formal Charge0
Complexity879.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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