10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Valproic Acid (NSC 93819) sodium salt Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine he
In vitro
Valproic acid acts through a distinct pathway that involves direct inhibition of histone deacetylase (IC(50) for HDAC1 = 0.4 mM). Valproic acid mimics the histone deacetylase inhibitor trichostatin A, causing hyperacetylation of histones in cultured cells. Valproic acid, like trichostatin A, also activates transcription from diverse exogenous and endogenous promoters. Valproic acid and trichostatin A have remarkably similar teratogenic effects in vertebrate embryos, while non-teratogenic analogues of valproic acid do not inhibit histone deacetylase and do not activate transcription. Valproic acid induces proliferation of peroxisomes in the rodent liver. Valproic acid at a concentration of 1 mM induces relief of this repression by Gal4 fusions of N‐CoR, TR or PPARδ in a cell line expressing the ligand‐binding domain of PPARδ fused to the DNA‐binding domain of the glucocorticoid receptor (GR) together with a GR‐controlled reporter gene. Valproic acid induces accumulation of hyperacetylated histone and inhibits HDAC activity. Valproic acid induces a specific type of differentiation characterized by reduced proliferation, morphological alterations, marker gene expression and particularly the accumulation of the AP-2 transcription factor as a potential marker of neuronal or neural crest cell-like differentiation in F9 teratocarcinoma cells. Valproic acid impairs cell proliferation or survival as indicated by decreased incorporation of [3H]thymidine in F9 and P19 teratocarcinoma cells.
In vivo
Valproic acid delays growth of the primary tumors in the MT‐450 rat breast cancer model.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
| Isomeric SMILES | CCCC(CCC)C(=O)[O-].[Na+] |
|---|---|
| WGK Germany | 3 |
| RTECS | YV7876000 |
| PubChem CID | 16760703 |
| Molecular Weight | 166.2 |
| Reaxy-Rn | 4212221 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro Water: 100 mg/mL warmed with 50ºC Water: bath (61.7 mM); DMSO: Insoluble; Ethanol: Insoluble; |
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| 1. Yuan Yuyang, Li Tianyu, Ye Zhichao, Feng Yuyao, Chen Zhe, Wang Yusen, Sun Yiqiao, Wu Haoyu, Yang Zhaodong, Wang Yifan, Zhang Yiran, Huang Liquan, Liang Bo. (2022) A One-Step Electropolymerized Biomimetic Polypyrrole Membrane-Based Electrochemical Sensor for Selective Detection of Valproate. Frontiers in Bioengineering and Biotechnology, [PMID:35242753] [10.3389/fbioe.2022.851692] |
| 2. Guo Qing, Gan Jun, Wang En-ze, Wei Yu-ming, Xu Jie, Xu Yun, Zhang Fei-fei, Cui Meng, Jia Meng-xing, Kong Ming-jian, Tang Qiong-yao, Zhang Zhe. (2025) Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model. ACTA PHARMACOLOGICA SINICA, [PMID:39870847] [10.1038/s41401-024-01457-8] |
| 3. Yingjun Xu, Yiming Han, Li Liu, Shanshan Han, Shibiao Zou, Bo Cheng, Fengbang Wang, Xunwei Xie, Yong Liang, Maoyong Song, Shaochen Pang. (2024) Highly sensitive response to the toxicity of environmental chemicals in transparent casper zebrafish. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:39032757] [10.1016/j.scitotenv.2024.174865] |
| 4. Hongshan Li, Rongqian Mo, Jiayu Yue, Rongrong Cheng, Dianyu Li, Yusuf M. Idres, Yanmei Yang, Yanqiao Wen, Xiangrong Li, Ruofei Feng. (2024) Sodium valproate promotes low metabolism and high protein expression in CHO-engineered cell lines. BIOCHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.bej.2024.109362] |
| 5. Yuwei Zhu, Wenbo Gao, Jianlin Zheng, Ye Bai, Xinyu Tian, Tengjin Huang, Zebin Lu, De Dong, Anqi Zhang, Changyou Guo, Zhiwei Huang. (2025) Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation. IMMUNITY, [PMID:40334665] [10.1016/j.immuni.2025.04.012] |
| 6. Yang Zhao, Feiya Zhu, Jiayu Xie, Yiting Wang, Motlalepula Matsabisa, Minke Tang. (2025) Panax notoginseng Flower Extract Attenuates Pentylenetetrazole-Induced Epilepsy by Restoring Glutamate Homeostasis. Brain Sciences, 15 (10): (1110). [PMID:41154204] [10.3390/brainsci15101110] |
| 7. Xin Gao, Xinjia Li, Yuanteng Zheng, Lijie Xia, Haonan Li, Yuqing Li, Attila Sik, Kechun Liu, Meng Jin. (2025) Rapid antiepileptic activity identification of isopimpinellin using a multi-model of epilepsy based on behavior-biomarker-BBB screening pipeline. PHYTOMEDICINE, [PMID:41351986] [10.1016/j.phymed.2025.157636] |
| 8. Xiangxi Meng, Yumo Tian, Sen Hu, Lili Wang, Yuxian Zhong, Kui Sun, Minghua Du. (2026) The protective effect of sodium valproate on rats with severe scald combined with seawater immersion. EUROPEAN JOURNAL OF MEDICAL RESEARCH, [PMID:41709307] [10.1186/s40001-026-04043-2] |
