Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
1-Aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.
| Canonical Smiles | C1=CC=C2C(=C1)N=NN2N |
|---|---|
| IUPAC Name | benzotriazol-1-amine |
| InChIKey | JCXKHYLLVKZPKE-UHFFFAOYSA-N |
| INCHI | 1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2 |
| Isomeric SMILES | C1=CC=C2C(=C1)N=NN2N |
| WGK Germany | 3 |
| RTECS | DM1235000 |
| Molecular Weight | 134.14 |
| Beilstein | 607843 |
| Reaxy-Rn | 607843 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=607843&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Benzotriazoles |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzotriazoles |
| Alternative Parents | Benzenoids Triazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Benzotriazole - Benzenoid - Heteroaromatic compound - 1,2,3-triazole - Triazole - Azole - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzotriazoles. These are organic compounds containing a benzene fused to a triazole ring (a five-membered ring with two carbon atoms and three nitrogen atoms). |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Sensitivity | Light Sensitive,Moisture Sensitive |
|---|---|
| Melt Point(°C) | 84 °C |
| Molecular Weight | 134.140 g/mol |
| XLogP3 | 0.900 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 134.059 Da |
| Monoisotopic Mass | 134.059 Da |
| Topological Polar Surface Area | 56.700 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 127.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xin Wang, Guangyun Ran, Yufen Liao, Bowen Gong, Chutian Wu, Rong Tan, Ying Liu, Shiyu Zhang, Ying Peng, Weiwei Li, Jiang Zheng. (2023) Formation of RNA adducts resulting from metabolic activation of spice ingredient safrole mediated by P450 enzymes and sulfotransferases. FOOD AND CHEMICAL TOXICOLOGY, [PMID:36841326] [10.1016/j.fct.2023.113688] |
| 2. Mingyu Zhang, Yaodong Hu, Wei Li, Chen Sun, Chunjing Guan, Ying Peng, Jiang Zheng. (2022) In Vitro and In Vivo Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol. CHEMICAL RESEARCH IN TOXICOLOGY, [PMID:35583464] [10.1021/acs.chemrestox.2c00048] |
| 3. Fei Li, Lin Di, Yuxin Liu, Qiuyun Xiao, Xiaoyu Zhang, Fuying Ma, Hongbo Yu. (2018) Carbaryl biodegradation by Xylaria sp. BNL1 and its metabolic pathway. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, [PMID:30359899] [10.1016/j.ecoenv.2018.10.051] |
| 4. Yukang Wang, Gaochen Jin, Shuyan Song, Yijun Jin, Xiaowen Wang, Shuaiqi Yang, Xingxing Shen, Yinbo Gan, Yuexing Wang, Ran Li, Jian-Xiang Liu, Jianping Hu, Ronghui Pan. (2024) A peroxisomal cinnamate:CoA ligase-dependent phytohormone metabolic cascade in submerged rice germination. DEVELOPMENTAL CELL, [PMID:38579719] [10.1016/j.devcel.2024.03.023] |
| 5. Sun Chen, Zhang Mingyu, Guan Chunjing, Li Weiwei, Peng Ying, Zheng Jiang. (2024) In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A. ARCHIVES OF TOXICOLOGY, [PMID:38369618] [10.1007/s00204-023-03674-2] |
| 6. Yuqian Chi, Xiaoliang Zhu, Yaxuan Chen, Xin Li, Ziyi Jiang, Xiaoyang Jian, Mengyuan Lian, Xiaodi Wu, Lei Wang, Mengmeng Sun, Xiaowei Shi. (2024) Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:38626834] [10.1016/j.ijbiomac.2024.131502] |
| 7. Siyu Liu, Guode Zhao, Yingyun Xu, Yang Wang, Zifang Ding, Weiwei Li, Ying Peng, Jiang Zheng. (2025) Metabolic activation and hepatic cytotoxicity of osthole mediated by cytochrome P450 enzymes. TOXICOLOGY LETTERS, [PMID:39793773] [10.1016/j.toxlet.2024.12.009] |
| 8. Li Shao, Jiajia Mo, Qinlong Xu, Guangwei He, Chunyu Xing, Zhaoxing Chu. (2024) Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method. XENOBIOTICA, [PMID:38501457] [10.1080/00498254.2024.2333007] |
| 9. Yan He, Zihao Cheng, Jingyu Zhang, Yu Chen, Guode Zhao, Hong Tang, Yufen Liao, Tingmin Ye, Ying Peng, Weiwei Li, Jiang Zheng. (2024) RNA Adduction Resulting from the Metabolic Activation of Myristicin by P450 Enzymes and Sulfotransferases. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38959404] [10.1021/acs.jafc.4c01676] |
| 10. Tingmin Ye, Chunping Tang, Dandan Yang, Qing Zhang, Yufen Liao, Jie Dai, Hong Tang, Changqiang Ke, Ying Peng, Yang Ye, Weiwei Li, Jiang Zheng. (2025) Metabolic activation and cytotoxicity of bavachin mediated by CYP3A in mice. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:40609922] [10.1016/j.cbi.2025.111630] |
| 11. Aolin Ma, Siqi Liu, Zhixuan Du, Longfei Zhu, Guanping Feng. (2025) Sulfonamides impede duckweed growth by inducing an excessive accumulation of salicylic acid. ENVIRONMENTAL AND EXPERIMENTAL BOTANY, [PMID:] [10.1016/j.envexpbot.2025.106224] |
| 12. Wei Wang, Jing Zhang, Gefei Huang, Iweta Pryjomska-Ray, Dietrich A. Volmer, Zongwei Cai. (2025) Tire-additive chemicals and their derivatives in urban road dust: Spatial distributions, exposures, and associations with tire and road wear particles. JOURNAL OF HAZARDOUS MATERIALS, [PMID:40024120] [10.1016/j.jhazmat.2025.137749] |
| 13. Pinzheng Li, Hengbin Zhang, Yingchun Chen, Shuanghui Lu, Huidi Jiang, Su Zeng, Hui Zhou. (2025) CYP-mediated metabolic divergence underpins oxoglaucine selectivity: Detoxification in healthy hepatocytes versus mitochondrial apoptosis in hepatocellular carcinoma. TOXICOLOGY IN VITRO, [PMID:41173113] [10.1016/j.tiv.2025.106170] |
| 14. Yuqin Chen, Zixia Hu, Guode Zhao, Mei Li, Ziying Jiang, Liangjia Xu, Jiannan Zheng, Weiwei Li, Ying Peng, Jiang Zheng. (2025) Metabolic activation, hepatic protein covalent binding, and cytotoxicity of arctigenin. TOXICOLOGY LETTERS, [PMID:41325899] [10.1016/j.toxlet.2025.111785] |
| 15. Xiu Chen, Xiaoyi Pan, Jieping Zhao, Huihui Jin, Hengbin Zhang, Yongbiao Song, Hui Zhou, Jianbiao Yao, Huidi Jiang. (2025) Interactions of neocryptotanshinone and human cytochrome P450 in silico and in vitro. TOXICOLOGY IN VITRO, [PMID:41419033] [10.1016/j.tiv.2025.106191] |
| 16. Lili Wu, Siyu Chen, Qiyuan Yang, Xing Li, Lingyan Liu, Shengjun Ji, Shuaiyuan Tang, Sihui Zhang, Yan Wang, Runzhi Chen, Zhikun Zhan. (2026) Cytochrome P450-Mediated Detoxification and NF-κB/NLRP3 Pathway-Driven Hepatotoxicity of Emodin: Multiomics and laboratory evidence. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:41579920] [10.1016/j.cbi.2026.111934] |