4-Iodophenol - ≥98% , CAS No.540-38-5

CAS: 540-38-5 Cat. No.: I107037 Molecular Weight: 220.01 Beilstein Registry Number: 1904544 EC Number: 208-745-5

GRADE & PURITY ≥98%

Synonyms

UNII-BH194BAK0B | CAS-540-38-5 | 4-Hydroxyphenyl iodide | 4-Iodophenol, purum, >=98.0% (GC) | CCRIS 668 | 4-Hydroxyiodobenzene | Paraiodophenol | para-iodophenol | para-iodo-phenol | SCHEMBL5514 | EN300-21417 | p-Iodophenol | p-iodo-phenol | P-IODOPHENOL

Storage

Protected from light,Room temperature,Cool

Shipped In

FedEx DG Service

Overview

Product Application:

4-Iodophenol is used as a synthetic block for the synthesis of:
Hydroxy biaromatic compounds are produced by PD-catalyzed Suzuki-Miyaura coupling reaction with arylboric acid.
Aryl substituted alkenes are produced by PD-catalyzed Heck reaction with acrylates.
Iodide - 4-aroxymethyl coumarin.
Hydroxystilbenes and psammaplysene A and B.

Specifications

Synonyms

UNII-BH194BAK0B | CAS-540-38-5 | 4-Hydroxyphenyl iodide | 4-Iodophenol, purum, >=98.0% (GC) | CCRIS 668 | 4-Hydroxyiodobenzene | Paraiodophenol | para-iodophenol | para-iodo-phenol | SCHEMBL5514 | EN300-21417 | p-Iodophenol | p-iodo-phenol | P-IODOPHENOL

Specifications & Purity

≥98%

Storage

Protected from light, Room temperature, Cool

Shipped In

FedEx DG Service

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488181216
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488181216
• Canonical Smiles: C1=CC(=CC=C1O)I
• IUPAC Name: 4-iodophenol
• InChIKey: VSMDINRNYYEDRN-UHFFFAOYSA-N
• INCHI: 1S/C6H5IO/c7-5-1-3-6(8)4-2-5/h1-4,8H
• Isomeric SMILES: C1=CC(=CC=C1O)I
• WGK Germany: 3
• RTECS: SL5600000
• UN Number: 3261
• Molecular Weight: 220.01
• Beilstein: 1904544
• Reaxy-Rn: 1904544
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1904544&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Phenols
      • Subclass Halophenols
        • Level5 Iodophenols
          • Level6 P-iodophenols

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Phenols
• Subclass: Halophenols
• Intermediate Tree Nodes: Iodophenols
• Direct Parent: P-iodophenols
• Alternative Parents: Iodobenzenes 1-hydroxy-2-unsubstituted benzenoids Aryl iodides Organooxygen compounds Organoiodides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: 4-iodophenol - 1-hydroxy-2-unsubstituted benzenoid - Iodobenzene - Halobenzene - Monocyclic benzene moiety - Aryl iodide - Aryl halide - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organoiodide - Organohalogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as p-iodophenols. These are iodophenols carrying a iodine at the C4 position of the benzene ring.
• External Descriptors: iodophenol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ALB Tchem Serum albumin (2651 Activities)

Discover Target: ALB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCRF-CEM (65223 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

L1210 (27553 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in alcohol and ether. Slightly soluble in water.
• Sensitivity: Light sensitive.
• Boil Point(°C): 138 °C/5 mmHg
• Melt Point(°C): 89-94°C
• Molecular Weight: 220.010 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 219.939 Da
• Monoisotopic Mass: 219.939 Da
• Topological Polar Surface Area: 20.200 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 66.900
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Wei Shengjie, Sun Yibing, Qiu Yun-Ze, Li Ang, Chiang Ching-Yu, Xiao Hai, Qian Jieshu, Li Yadong.  (2023)  Self-carbon-thermal-reduction strategy for boosting the Fenton-like activity of single Fe-N4 sites by carbon-defect engineering.  Nature Communications,  14  (1): (1-15).  [PMID:37985662] [10.1038/s41467-023-43040-5]

2. Min Zhao, Ting Li, Yizhan Zhang, Jiaming Gan, Yiting Zhao, Xin Yu, Lei Wang.  (2023)  Kinetic modeling and mechanisms of parahalogenated phenols degradation by UV222/H2O2.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2023.140255]

3. Shaoyuan Guo, Xinli Tong, Lingwu Meng, Guobao Yang.  (2023)  A sustainable iron-catalyzed aerobic oxidative C–C and C–O bond cleavage of a lignin model to phenol and methyl benzoate.  Catalysis Science & Technology,  13  (6): (1748-1754).  [PMID:] [10.1039/D2CY01763F]

4. Mingyang Gao, Jiamin Wang, Weixiang Shang, Yuchao Chai, Weili Dai, Guangjun Wu, Naijia Guan, Landong Li.  (2022)  Zeolite-encaged palladium catalysts for heterogeneous Suzuki-Miyaura cross-coupling reactions.  CATALYSIS TODAY,      [PMID:] [10.1016/j.cattod.2022.02.011]

5. Ruxia Liu, Ruirui Shi, Wenting Zou, Wenhua Chen, Xianchao Yin, Fengchun Zhao, Zhengyou Yang.  (2020)  Highly sensitive phage-magnetic-chemiluminescent enzyme immunoassay for determination of zearalenone.  FOOD CHEMISTRY,      [PMID:32387950] [10.1016/j.foodchem.2020.126905]

6. Jing Liu, Jing Wang, Jie Zhang, Yang Mu.  (2019)  Iodo-trihalomethanes formation during chlorination and chloramination of iodide-containing waters in the presence of Cu2+.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:30928739] [10.1016/j.scitotenv.2019.03.356]

7. Zhi Zhang, Yueping Guan, Guoli Xu, Chen Guo.  (2019)  A new washing-free immunosensor for tumor marker detection based on functionalized Fe3O4 submicron particles.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2019.03.064]

8. Enze Sheng, Mei Du, Jiachuan Yang, Xiude Hua, Minghua Wang.  (2018)  Development of immunoassays for detecting oxyfluorfen residue in agricultural and environmental samples.  RSC Advances,  8  (9): (5020-5025).  [PMID:35539517] [10.1039/C7RA12445G]

9. Shenguang Ge, Linlin Liang, Feifei Lan, Yan Zhang, Yanhu Wang, Mei Yan, Jinghua Yu.  (2016)  Photoelectrochemical immunoassay based on chemiluminescence as internal excited light source.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2016.04.166]

10. Ran Chen, Zhongwei An, Feng Li, Xinbing Chen, Pei Chen.  (2016)  Synthesis and physical properties of tolane liquid crystals containing 2,3-difluorophenylene and terminated by a tetrahydropyran moiety.  LIQUID CRYSTALS,      [PMID:] [10.1080/02678292.2015.1125959]

11. Yue Zhang, Zhiyong Li, Huiyong Wang, Xiaopeng Xuan, Jianji Wang.  (2016)  Efficient separation of phenolic compounds from model oil by the formation of choline derivative-based deep eutectic solvents.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2016.03.014]

12. Kun Hu, Pei Chen, Qiang Weng, Dingqian Shi, Ran Chen, Xinbing Chen, Zhongwei An.  (2015)  Improved mesophase stability of benzoxazole derivatives via dipole moment modification.  LIQUID CRYSTALS,      [PMID:] [10.1080/02678292.2015.1084656]

13. Zi-Ming Zhou, Zhe Feng, Jun Zhou, Bi-Yun Fang, Zhi-Ya Ma, Bo Liu, Yuan-Di Zhao, Xue-Bin Hu.  (2014)  Quantum dot-modified aptamer probe for chemiluminescence detection of carcino-embryonic antigen using capillary electrophoresis.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2014.12.087]

14. Zi-Ming Zhou, Zhe Feng, Jun Zhou, Bi-Yun Fang, Xiao-Xiao Qi, Zhi-Ya Ma, Bo Liu, Yuan-Di Zhao, Xue-Bin Hu.  (2014)  Capillary electrophoresis-chemiluminescence detection for carcino-embryonic antigen based on aptamer/graphene oxide structure.  BIOSENSORS & BIOELECTRONICS,      [PMID:25299985] [10.1016/j.bios.2014.09.050]

15. Zi-Ming Zhou, Yong Yu, Ming-Zhen Zhang, Jun Chen, Qiong-Qiong Ren, Ji-Tao Song, Bo Liu, Zhi-Ya Ma, Yuan-Di Zhao.  (2014)  Chemiluminescence detection of lead (II) using ‘8–17’ DNAzyme and hemin/G-quadruplex with high sensitivity and selectivity.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2014.05.007]

16. Lei Ma, Yanyan Sun, Xuejun Kang, Yakun Wan.  (2014)  Development of nanobody-based flow injection chemiluminescence immunoassay for sensitive detection of human prealbumin.  BIOSENSORS & BIOELECTRONICS,      [PMID:24874660] [10.1016/j.bios.2014.04.026]

17. Yuan Zhou, Tao Zhou, Rui Zhou, Yonggang Hu.  (2013)  Chemiluminescence immunoassay for the rapid and sensitive detection of antibody against porcine parvovirus by using horseradish peroxidase/detection antibody-coated gold nanoparticles as nanoprobes.  LUMINESCENCE,  29  (4): (338-343).  [PMID:23832716] [10.1002/bio.2549]

18. Jusheng Lu, Wei Wei, Lihong Yin, Yuepu Pu, Songqin Liu.  (2012)  Flow injection chemiluminescence immunoassay of microcystin-LR by using PEI-modified magnetic beads as capturer and HRP-functionalized silica nanoparticles as signal amplifier.  ANALYST,  138  (5): (1483-1489).  [PMID:23330150] [10.1039/C2AN36513H]

19. Qinglong Zhu, Pin Lv, Yuxi Zhang, Yijie Wang, Gan Luo, Ziqi An, Min Hu, Kaiwen Hu, Wangnan Li, Feifei Yang, Bo Zhang, Zhiliang Ku, Yi-Bing Cheng, Jianfeng Lu.  (2024)  LiTFSI-Free Hole Transport Materials for Robust Perovskite Solar Cells and Modules with High Efficiencies.  ACS Applied Materials & Interfaces,      [PMID:38343187] [10.1021/acsami.3c17468]

20. Zhihui Guo, Mingya Deng, Wenwen Fang, Kang Zheng, Min Liao, Yulong Wang, Qingkui Fang.  (2024)  Quantitative determination of prothioconazole in wheat grain, soybean, and pond water based on a polyclonal antibody.  Analytical Methods,      [PMID:38855900] [10.1039/D4AY00441H]

21. Hui Chen, Zhiyuan Zhuang, Naihan Xu, Ying Feng, Kaixin Fang, Chunyan Tan, Ying Tan.  (2024)  Simple, Visual, Point-of-Care SARS-CoV-2 Detection Incorporating Recombinase Polymerase Amplification and Target DNA–Protein Crosslinking Enhanced Chemiluminescence.  Biosensors-Basel,  14  (3): (135).  [PMID:38534242] [10.3390/bios14030135]

22. Hongyang Li, Xiaopeng Zhang, Meimei Zhu, Dongwen Zou, Jingyan Liu, Meili Xu, Yaowu He, Hong Meng.  (2025)  All-Solid-State Transparent-to-Black Electrochromic Smart Window for Building Energy Saving.  ACS Energy Letters,      [PMID:] [10.1021/acsenergylett.5c01557]

23. Pengjia Sun, Ping Sun, Yingsen Fang, Hui Liu, Bitao Xiong, Hui Wang, Xingao Li.  (2023)  Enhanced degradation of bisphenol S in water using a combination process of electrochemical oxidation with periodate activation.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2023.104203]

24. Pengjia Sun, Jian Xiong, Ping Sun, Yingsen Fang, Hongxia Liu, Hui Liu, Bitao Xiong, Hui Wang, Xing'ao Li.  (2023)  Additional O doping significantly improved the catalytic performance of Mn/O co-doped g-C3N4 for activating periodate and degrading organic pollutants.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2023.125593]

25. Zhuohua Dai, Guangfa Wang, Fangfang Xiao, Da Lei, Xincun Dou.  (2023)  Amorphous Copper-Based Nanoparticles with Clusterization-Triggered Phosphorescence for Ultrasensing 2,4,6-Trinitrotoluene.  ADVANCED MATERIALS,  35  (24): (2300526).  [PMID:36929680] [10.1002/adma.202300526]

26. Hongyang Li, Yaowu He, Dongwen Zou, Meili Xu, Jingyan Liu, Zizheng Tong, Meimei Zhu, Jinyuan Tang, Tianhe Xu, Lijia Yan, Hong Meng.  (2025)  Smart energy-saving windows enabled by transparent-to-black ultra-low voltage polytriphenylamines.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.170887]

27. Yuqing Feng, Hongxia Liu, Yongxing Shang, Yingsen Fang, Shumei Gao, Ping Sun, Bitao Xiong, Hui Wang, Hui Liu, Mingbao Feng.  (2026)  Single-atomic Fe−N3C sites with optimized oxophilicity for high-efficiency periodate activation toward pollutant abatement via preferential 1O2.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2026.126445]