≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
4-Methoxyphenylacetic acid belongs to the class of aryl alkanoic acids, with a broad-spectrum of applications, which includes its role as an intermediate in synthetic organic chemistry, building block material for the production of a variety of essential drugs, an additive in the manufacture of unsubstituted indigo dyes and corrosion inhibitor for aluminum in acidic and alkaline solutions. It is a structural analog of 2-(4-methoxyphenoxy)propanoic acid, reported to occur in cocoa products
4-Methoxyphenylacetic acid can be used:
•To prepare methyl 4-methoxyphenylacetate by esterification with dimethyl carbonate using mesoporous sulfated zirconia catalyst.
•As a ligand to synthesize pharmacologically important dinuclear gallium(III) and phenyltin(IV) carboxylate metal complexes.
•As a reactant to synthesize hydroxylated (E)-stilbenes by reacting with substituted benzaldehydes via Perkin reaction.
| Canonical Smiles | COC1=CC=C(C=C1)CC(=O)O |
|---|---|
| IUPAC Name | 2-(4-methoxyphenyl)acetic acid |
| InChIKey | NRPFNQUDKRYCNX-UHFFFAOYSA-N |
| INCHI | 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H,6H2,1H3,(H,10,11) |
| Isomeric SMILES | COC1=CC=C(C=C1)CC(=O)O |
| WGK Germany | 3 |
| RTECS | AI8960000 |
| Molecular Weight | 166.17 |
| Beilstein | 1101737 |
| Reaxy-Rn | 1101737 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1101737&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Phenol ethers |
| Subclass | Anisoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Anisoles |
| Alternative Parents | Phenoxy compounds Methoxybenzenes Alkyl aryl ethers Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenoxy compound - Methoxybenzene - Anisole - Alkyl aryl ether - Monocyclic benzene moiety - Monocarboxylic acid or derivatives - Ether - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. |
| External Descriptors | monocarboxylic acid - monomethoxybenzene |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2526628 | Certificate of Analysis | Jun 30, 2025 | S736415 |
| F2526629 | Certificate of Analysis | Jun 30, 2025 | S736415 |
| F2526630 | Certificate of Analysis | Jun 30, 2025 | S736415 |
| F2526636 | Certificate of Analysis | Jun 30, 2025 | S736415 |
| Solubility | Solubility in Methanol very faint turbidity |
|---|---|
| Sensitivity | heat sensitive |
| Boil Point(°C) | 140 °C/3 mmHg |
| Melt Point(°C) | 85-88°C |
| Molecular Weight | 166.170 g/mol |
| XLogP3 | 1.400 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 166.063 Da |
| Monoisotopic Mass | 166.063 Da |
| Topological Polar Surface Area | 46.500 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 148.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Zhenyuan Mei, Yu Cai, Zizheng Tong, Dongwen Zou, Hongyang Li, Jingyan Liu, Meimei Zhu, Yudan Liang, Hong Meng, Yaowu He. (2025) All-in-One Complementary Electrochromism for Ultra-Stable Broadband Smart Windows. ACS Applied Materials & Interfaces, [PMID:41264915] [10.1021/acsami.5c16749] |
