≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
Targets
caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM
In vitro
A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes.
In vivo
Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury.
Cell Research(from reference)
Cell lines：BMDM cells
Concentrations：10 μM
Incubation Time：30 mins
| Canonical Smiles | CC(C)CC(C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C(CC1=CC=CC=C1)NC(=O)C |
|---|---|
| IUPAC Name | (3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid |
| InChIKey | UCWNTWGHVCSMJP-WPUDHWPRSA-N |
| INCHI | 1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1 |
| Molecular Weight | 569.05 |
| Reaxy-Rn | 57566578 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=57566578&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2423466 | Certificate of Analysis | Jan 15, 2024 | A414490 |
| B2423763 | Certificate of Analysis | Jan 15, 2024 | A414490 |
| B2423764 | Certificate of Analysis | Jan 15, 2024 | A414490 |
| B2423765 | Certificate of Analysis | Jan 15, 2024 | A414490 |
| B2423767 | Certificate of Analysis | Jan 15, 2024 | A414490 |
| B2423768 | Certificate of Analysis | Jan 15, 2024 | A414490 |
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (175.73 mM); Ethanol: 25 mg/mL (43.93 mM); Water: 2 mg/mL (3.51 mM); |
|---|---|
| Sensitivity | Hygroscopic ;Light sensitive |
