GRADE & PURITY 10mM in DMSO

Synonyms

PT-9 | N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Betahistine (PT-9) is ahistamine H3receptor inhibitor withIC50of 1.9 μM.
In vitro

Betahistine progressively enhances cAMP formation with a maximal effect, observed up to 10 nM, in CHO(H3R) cells incubated with 3 μM forskolin. In contrast, at concentrations higher than 10 nM betahistine progressively inhibits cAMP formation in CHO(H3R) cells incubated with 3 μM forskolin. Betahistine progressively reduces A23187-evoked [³H]arachidonic acid release (EC50=0.1 nM) with a maximal effect, observed up to 30 nM A23187-evoked [³H]arachidonic acid release from CHO(H3R) cells. Betahistine progressively enhanced the release of A23187-evoked [³H]arachidonic acid from CHO(H3R) cells at concentrations higher than 30 nM.

In vivo

Betahistine (< 30 mg/kg) increases t-MeHA levels in a dose-dependent manner with an ED50 of 2 mg/kg and a maximal effect of ∼35% reached at 30 mg/kg in mouse brain. Betahistine (16 mg twice per day for 3 months) has a significant effect on the frequency, intensity and duration of vertigo attacks, associated symptoms and the quality of life also are significantly improved in patients with Meniere\'s disease. Betahistine-dihydrochloride (16 mg tid and 48 mg tid) shows that the number of attacks per month decreased in both doses over time in Meni鑢e\'s disease. Betahistine (50 mg/kg) treatment induces symmetrical changes with up-regulation of histidine decarboxylase mRNA in the tuberomammillary nucleus and reduction of [³H]N-alpha-methylhistamine labeling in both the tuberomammillary nucleus, the vestibular nuclei complex and nuclei of the inferior olive in brain sections of cats.
Cell Data

cell lines：Calu-6 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

PT-9 | N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1.9 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CNCCC1=CC=CC=N1.Cl.Cl
• WGK Germany: 3
• PubChem CID: 68643
• Molecular Weight: 209.12

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Water: 36 mg/mL (199.82 mM); DMSO: Insoluble
• Melt Point(°C): 150-154°C