GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

SL 75212 | 1-​[4-​[2-​(cyclopropylmethoxy)​ethyl]​phenoxy]​-​3-​[(1-​methylethyl)​amino]​-2-​propanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Betaxolol (SL 75212) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥96%

Specifications

Synonyms

SL 75212 | 1-​[4-​[2-​(cyclopropylmethoxy)​ethyl]​phenoxy]​-​3-​[(1-​methylethyl)​amino]​-2-​propanol

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Betaxolol (SL 75212) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor

Names and Identifiers

• Isomeric SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
• Molecular Weight: 307.43
• Reaxy-Rn: 1991268
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1991268&ln=

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (1 Activities)

Discover Target: ADRB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor (3 Activities)

Discover Target: ADRB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro
• Melt Point(°C): 61-63°C

References

1. Wu Jia, Xiao Xue, Li Zhenqun, Jia Li.  (2019)  Enantioseparation of chiral β-blockers using polynorepinephrine-coated nanoparticles and chiral capillary electrophoresis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  411  (10): (2121-2129).  [PMID:30734853] [10.1007/s00216-019-01641-4]