(-)-Bicuculline methiodide - ≥96% , CAS No.55950-07-7

CAS: 55950-07-7 Cat. No.: B275169 Molecular Weight: 509.29 PubChem CID: 185826

GRADE & PURITY ≥96%

Synonyms

DTXSID40971361 | (5R)-5-[(6S)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium Iodide | AKOS030242442 | Bicuculline methiodide | 55950-07-7

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Store at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months.

GABA receptor antagonist. 

Specifications

Synonyms

DTXSID40971361 | (5R)-5-[(6S)-6, 8-Dihydro-8-oxofuro[3, 4-e]-1, 3-benzodioxol-6-yl]-5, 6, 7, 8-tetrahydro-6, 6-dimethyl-1, 3-dioxolo[4, 5-g]isoquinolinium Iodide | AKOS030242442 | Bicuculline methiodide | 55950-07-7

Specifications & Purity

≥96%

Biochemical and Physiological Mechanisms

Water-soluble GABA A antagonist. Methiodide salt of (+)-bicuculline . Actions on neuronal Ca 2+ -activated K + channels reported.

Source

Synthetic

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. To be used on the same day after reconstitution. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥96%

Names and Identifiers

• Pubchem Sid: 504757733
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757733
• Canonical Smiles: C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[I-]
• IUPAC Name: (6S)-6-[(5R)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one;iodide
• InChIKey: HKJKCPKPSSVUHY-VOMIJIAVSA-M
• INCHI: 1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m1./s1
• Isomeric SMILES: C[N+]1(CCC2=CC3=C(C=C2[C@@H]1[C@@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[I-]
• PubChem CID: 185826
• Molecular Weight: 509.29

Chemical and Physical Properties

• Solubility: Soluble in water to 10 mM
• Sensitivity: light sensitive；Moisture sensitive
• Melt Point(°C): 175-177°C
• Molecular Weight: 509.300 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 509.034 Da
• Monoisotopic Mass: 509.034 Da
• Topological Polar Surface Area: 63.200 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 655.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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