CAIX Inhibitor S4 - Moligand™, 10 mM in DMSO , CAS No.1330061-67-0

CAS: 1330061-67-0 Cat. No.: C1494402 Molecular Weight: 335.38 PubChem CID: 53342705

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII ( CA IX/XII) , with a K i of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I ( K i =546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC(=CC(=C1)NC(=O)NC2=CC=C(C=C2)OS(=O)(=O)N)C
• PubChem CID: 53342705
• Molecular Weight: 335.38

References

1. Narmadha Manoranjan, Feng Zhang, Zhenyi Wang, Yanping Dong, Wangxi Fang, Yatao Zhang, Yuzhang Zhu, Jian Jin.  (2020)  A Single-Walled Carbon Nanotube/Covalent Organic Framework Nanocomposite Ultrathin Membrane with High Organic Solvent Resistance for Molecule Separation.  ACS Applied Materials & Interfaces,      [PMID:33169985] [10.1021/acsami.0c14825]