10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids.
In vitro
Carbazochrome (0.1–1 M) reverses the barrier dysfunction induced by tryptase, thrombin and bradykinin without affecting the endothelial permeability enhanced by Ca(2+) ionophores such as ionomycin and A23187 or phorbol 12-myristate 13-acetate. Carbazochrome reverses the tryptase-induced formation of actin stress fibres and disruption of VE-cadherin in the monolayers of cultured porcine aortic endothelial cells (PAECs). Carbazochrome (0.1-10 M) reduces concentration-dependently the enhancement of [(3)H]inositol triphosphate formation from [(3)H]myo-inositol induced by bradykinin and thrombin. Carbazochrome significantly blocks the hyperpermeability induced in cultured bovine endothelial cells by tryptase, thrombin and proteinase-activated receptor-2 agonist peptide (SLIGKV-NH(2)). Carbazochrome significantly decreases the t-PA:Ag in the culture medium of human umbilical vein endothelial cells (HUVEC), while it has no significant effect on the PAI-1:Ag.
In vivo
Carbazochrome (10 mg/kg) reverses the ioxaglate-induced vascular hyperpermeability in a dose-dependent manner in rats. Carbazochrome (10 mg/kg) significantly inhibits the decrease in arterial pO(2).
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CN1C(CC2=CC(=C(C=C21)O)N=NC(=O)N)S(=O)(=O)[O-].[Na+] |
|---|---|
| Molecular Weight | 322.27 |
| Reaxy-Rn | 55380936 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=55380936&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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