Cardiolipin solution from bovine heart - ≥97%(TLC), 4.7-5.3 mg/mL in ethanol

Cat. No.: C485580

GRADE & PURITY ≥97%(TLC), 4.7-5.3 mg/mL in ethanol

Synonyms

Diphosphatidylglycerol solution

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Cardiolipin (CL) is a complex lipid with a dimeric structure. It has four acyl chains and two phosphatidyl moieties. Its phosphatidyl moieties are linked to the glycerol backbone. Around 15-20 percent of the inner mitochondrial membrane accounts for cardiolipin.
Cardiolipin is a unique phospholipid found exclusively within the mitochondrial inner membrane. This specific localization allows Cardiolipin to exert crucial influence on mitochondrial structure and function. Deviations in Cardiolipin content, structure, or localization can lead to impaired mitochondrial activity, contributing to various diseases like cancer, neurological disorders, cardiovascular conditions, and metabolic diseases. As Cardiolipin plays a crucial role in mitochondrial function, it holds immense potential for biomarker development and finds application in cardiovascular, neuroscience, cancer, diabetes, and metabolomics research.

Application：

Cardiolipin solution from bovine heart has been used:
for coating Corning 96-well enzyme immunoassay/radioimmunoassay (EIA/RIA) plate to perform enzyme-linked immunosorbent assay (ELISA)-based cardiolipin binding assay
in lipid analysis along with phosphatidylglycerol (PG) to comigrate the radiolabeled lipids to identify PG and cardiolipin (CL)
in coating ELISA plates for antiphospholipid antibodies (aPL) assays

Characteristics and advantages：

High-quality molecule suitable for mulitple research applications
Commonly employed in Metabolomics and Biochemical studies

Specifications

Synonyms

Diphosphatidylglycerol solution

Specifications & Purity

≥97%(TLC), 4.7-5.3 mg/mL in ethanol

Biochemical and Physiological Mechanisms

Cardiolipin (CL) plays a key role in mitochondrial biogenesis, fusion and fission, respiration, and protein import. It participates in the cellular processes outside of the mitochondria like cell wall biogenesis, aging, vacuole homeostasis, the cell cycle

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

>80% polyunsaturated fatty acid content, primarily linoleic acid.', '

Purity

≥97%(TLC)

References

1. Xia Xiao, Yanhu Huang, Wei Liu, Yuan Liu, Haijie Zhang, Chuang Meng, Zhiqiang Wang.  (2025)  Acetylshikonin Derived From Arnebia euchroma (Royle) Johnst Kills Multidrug-Resistant Gram-Positive Pathogens In Vitro and In Vivo.  PHYTOTHERAPY RESEARCH,      [PMID:39764664] [10.1002/ptr.8427]