Caspase-1 Inhibitor II, CAS No.178603-78-6

CAS: 178603-78-6 Cat. No.: C343789 Molecular Weight: 540.99

GRADE & PURITY ≥95%

Overview

Caspase-1 Inhibitor II (Ac-YVAD-CMK) is a cell-permeable and irreversible inhibitor of caspase-1 (K|i|= 760 pM), caspase-4, and caspase-5. It also inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)|2|tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.|Additional caspase-1 inhibitors available:|caspase-1 inhibitor |caspase-1 inhibitor VI |Caspase-1 Inhibitor IV |Caspase-1 Inhibitor I

Specifications

Product Name

Caspase-1 Inhibitor II, CAS No.178603-78-6

Synonyms

Ac-YVAD-CMK | IL-1β Converting Enzyme (ICE) Inhibitor II

Specifications & Purity

≥95%

Sequence

Ac-Tyr-Val-Ala-Asp-CMK

Action Type

INHIBITOR

Note

Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Protect from light, moisture sensitive.

CAS

178603-78-6

Molecule Type

Small molecule

Storage and Shipping

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Peptidomimetics
      • Subclass Hybrid peptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Peptidomimetics
• Subclass: Hybrid peptides
• Intermediate Tree Nodes: Not available
• Direct Parent: Hybrid peptides
• Alternative Parents: Tyrosine and derivatives Phenylalanine and derivatives Valine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Beta amino acids and derivatives Alanine and derivatives Amphetamines and derivatives Gamma-keto acids and derivatives 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Alpha-chloroketones Acetamides Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Alkyl chlorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Hybrid peptide - Tyrosine or derivatives - Phenylalanine or derivatives - Valine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alanine or derivatives - Beta amino acid or derivatives - Amphetamine or derivatives - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Gamma-keto acid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Fatty acyl - Benzenoid - N-acyl-amine - Keto acid - Fatty amide - Monocyclic benzene moiety - Alpha-haloketone - Alpha-chloroketone - Acetamide - Secondary carboxylic acid amide - Ketone - Carboxamide group - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl chloride - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y