DNA Alkylator/Crosslinker

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  1. Chlorambucil, DNA inhibitor
    CAS: 305-03-3 EC Number: 206-162-0 Formula: C14H19Cl2NO2 Molecular Weight: 304.21
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C154015
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    IUPAC Name
    4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
    SMILES
    C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
    InChIKey
    JCKYGMPEJWAADB-UHFFFAOYSA-N
    InChI
    1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
    Synonyms
    RCRA waste no. U035 | Chloorambucol | Elcoril | Linfolizin | 4-[Bis(2-chloroethyl)amino]benzenebutyric acid | Chloram...
  2. Pipobroman, DNA inhibitor
    CAS: 54-91-1 PubChem CID: 4842 Formula: C10H16Br2N2O2 Molecular Weight: 356.05
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P193879
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    IUPAC Name
    3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
    SMILES
    C1CN(CCN1C(=O)CCBr)C(=O)CCBr
    InChIKey
    NJBFOOCLYDNZJN-UHFFFAOYSA-N
    InChI
    1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
    Synonyms
    BSPBio_002574 | CHEBI:8242 | EN300-7415033 | PIPOBROMAN [INN] | s4447 | SCHEMBL4889 | Spectrum2_000912 | Pipobromanum...
  3. Melphalan(L-PAM), DNA inhibitor
    CAS: 148-82-3 EC Number: 205-726-3 Formula: C13H18Cl2N2O2 Molecular Weight: 305.20
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥90%
    ● In Stock — US warehouse, ships to EU* Item #: M191037
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    IUPAC Name
    (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
    SMILES
    C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
    InChIKey
    SGDBTWWWUNNDEQ-LBPRGKRZSA-N
    InChI
    1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
    Synonyms
    MELPHALAN [HSDB] | MELPHALAN [VANDF] | Spectrum2_000074 | 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine | 4-[Bis(2-chl...
  4. VAL-083, DNA cross-linking agent
    CAS: 23261-20-3 PubChem CID: 15942827 Formula: C6H10O4 Molecular Weight: 146.14
    ● In Stock — US warehouse, ships to EU* Item #: V125883
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    IUPAC Name
    (1S,2R)-1-[(2S)-oxiran-2-yl]-2-[(2R)-oxiran-2-yl]ethane-1,2-diol
    SMILES
    C1C(O1)C(C(C2CO2)O)O
    InChIKey
    AAFJXZWCNVJTMK-GUCUJZIJSA-N
    InChI
    1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
    Synonyms
    (1R,2S)-1-((R)-oxiran-2-yl)-2-((S)-oxiran-2-yl)ethane-1,2-diol | MS-22831 | (1S,2R)-1-[(2S)-oxiran-2-yl]-2-[(2R)-oxir...
  5. Palifosfamide, DNA cross-linking agent
    CAS: 31645-39-3 Formula: C4H11Cl2N2O2P Molecular Weight: 221.02
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P125463
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    IUPAC Name
    bis(2-chloroethylamino)phosphinic acid
    SMILES
    C(CCl)NP(=O)(NCCCl)O
    InChIKey
    BKCJZNIZRWYHBN-UHFFFAOYSA-N
    InChI
    1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
    Synonyms
    DB05668 | IPAM | 6A4U6NN813 | Isophosphoramide mustard | Isophosphamide mustard | N,N'-Di-(2-chloroethyl)phosphorodia...
  6. Miriplatin monohydrate
    CAS: 250159-48-9 PubChem CID: 23725065 Formula: C34H68N2O4Pt(anhy) Molecular Weight: 763.99(anhy)
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: M190878
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    Synonyms
    Cyclohexane-(1R,2R)-diamineplatinum(II) dimyristate | MPT | SM-11355
  7. Azoxymethane
    CAS: 25843-45-2 EC Number: 620-649-9 Formula: C2H6N2O Molecular Weight: 74.08
    Liquid ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: A169090
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    IUPAC Name
    methyl-methylimino-oxidoazanium
    SMILES
    CN=[N+](C)[O-]
    InChIKey
    DGAKHGXRMXWHBX-UHFFFAOYSA-N
    InChI
    1S/C2H6N2O/c1-3-4(2)5/h1-2H3
    Synonyms
    (E)-dimethyldiazen-1-ium-1-olate | FT-0622536 | (Methyl-ONN-azoxy)methane | BCP30116 | Q794084 | CCRIS 67 | J-016148 ...
  8. Cyclophosphamide monohydrate, DNA inhibitor
    CAS: 6055-19-2 EC Number: 640-398-9 PubChem CID: 22420 Formula: C7H15Cl2N2O2P·H2O Molecular Weight: 279.1
    Solid ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: C106991
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    IUPAC Name
    N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine;hydrate
    SMILES
    C1CNP(=O)(OC1)N(CCCl)CCCl.O
    InChIKey
    PWOQRKCAHTVFLB-UHFFFAOYSA-N
    InChI
    1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
    Synonyms
    2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate | CCG-40013 | Cyclophosphamide hydrate | Cyclophos...
  9. Cyclophosphamide
    CAS: 50-18-0 EC Number: 200-015-4 Formula: C7H15Cl2N2O2P Molecular Weight: 261.09
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C126044
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    IUPAC Name
    N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
    SMILES
    C1CNP(=O)(OC1)N(CCCl)CCCl
    InChIKey
    CMSMOCZEIVJLDB-UHFFFAOYSA-N
    InChI
    1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
    Synonyms
    Cytoxan | Clafen | Neosar | CTX | 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide | Cyclophos...
  10. Trioxsalen, DNA inhibitor
    CAS: 3902-71-4 EC Number: 223-459-0 PubChem CID: 5585 Formula: C14H12O3 Molecular Weight: 228.25
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: T161750
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    IUPAC Name
    2,5,9-trimethylfuro[3,2-g]chromen-7-one
    SMILES
    CC1=CC(=O)OC2=C1C=C3C=C(OC3=C2C)C
    InChIKey
    FMHHVULEAZTJMA-UHFFFAOYSA-N
    InChI
    1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
    Synonyms
    2,5,9-trimethylfuro[3,2-g]chromen-7-one | CAS-3902-71-4 | NSC 71047 | HMS2879M06 | HMS501C22 | Trioxysalene | 2',4,8-...
  11. Procarbazine HCl, DNA inhibitor
    CAS: 366-70-1 EC Number: 206-678-6 Formula: C12H19N3O·HCl Molecular Weight: 257.76
    ● In Stock — US warehouse, ships to EU* Item #: P129854
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    IUPAC Name
    4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride
    SMILES
    CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
    InChIKey
    DERJYEZSLHIUKF-UHFFFAOYSA-N
    InChI
    1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
    Synonyms
    Nathulane | DTXCID001190 | Ro 4-646711 | CCRIS 531 | Natulan hydrochloride | Chlorhydrate de 1-methyl 2 p (isopropylc...
  12. Bendamustine HCl, DNA inhibitor
    CAS: 3543-75-7 EC Number: 631-540-0 Formula: C16H21Cl2N3O2·HCl Molecular Weight: 394.72
    Solid ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: B124707
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    IUPAC Name
    4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydrochloride
    SMILES
    CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl
    InChIKey
    ZHSKUOZOLHMKEA-UHFFFAOYSA-N
    InChI
    1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H
    Synonyms
    AS-15856 | SDX-105 (Cytostasane) HCl | 2-Benzimidazolebutyric acid, monohydrochloride | BB164239 | BCP02107 | BENDAMU...
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Frequently Asked Questions

Which compounds are listed for DNA Alkylator/Crosslinker?
Compounds associated with DNA Alkylator/Crosslinker are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does DNA Alkylator/Crosslinker sit within Cell Cycle/DNA Damage?
DNA Alkylator/Crosslinker is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from DNA Alkylator/Crosslinker?
For compounds listed under DNA Alkylator/Crosslinker, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for DNA Alkylator/Crosslinker?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring DNA Alkylator/Crosslinker, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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