Cilostazol (OPC-13013) - Moligand™, 10mM in DMSO , Phosphodiesterase 3A inhibitor, CAS No.73963-72-1, Phosphodiesterase 3A inhibitor

CAS: 73963-72-1 Cat. No.: C408872 Molecular Weight: 369.46 EC Number: 689-122-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor withIC50of 0.2 μM and inhibitor of adenosine uptake.
In vitro

Cilostazol (OPC-13013) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 (PDE3) and subsequent elevation of intracellular cAMP levels. Cilostazol inhibits platelet aggregation. Cilostazol also possesses the ability to inhibit adenosine uptake. Elevation of interstitial adenosine by cilostazol in the heart is shown to reduce increases in cAMP caused by the PDE3-inhibitory action of cilostazol, thus attenuating the cardiotonic effects. Cilostazol is reported to inhibit smooth muscle cell proliferation. Cilostazol relaxes vascular smooth muscle and causes vasodilatation. Cilostazol inhibits the cytokine-induced expression of monocyte chemoattractant protein-1 (MCP-1). Cilostazol reduced plasma triglycerides and raised plasma HDL-cholesterol .

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3, 4-dihydroquinolin-2(1H)-one

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Phosphodiesterase 3A inhibitor

Product Properties

• ALogP: 3.1

Names and Identifiers

• Isomeric SMILES: C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
• WGK Germany: 2
• RTECS: VC8277500
• Molecular Weight: 369.46
• Reaxy-Rn: 3632107
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3632107&ln=

Associated Targets(Human)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A (2 Activities)

Discover Target: PDE3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B (1 Activities)

Discover Target: PDE3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 74 mg/mL (199.76 mM); Water: Insoluble; Ethanol: Insoluble
• Melt Point(°C): 160 °C

References

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2. Xinyu Shan, Yichao Lu, Zhenyu Luo, Xiaoqi Zhao, Mei Pang, Hang Yin, Xuemeng Guo, Huanli Zhou, Junlei Zhang, Jiaxin Huang, Yingying Shi, Jinfang Lou, Lihua Luo, Jian You.  (2024)  A Long-Acting Lyotropic Liquid Crystalline Implant Promotes the Drainage of Macromolecules by Brain-Related Lymphatic System in Treating Aged Alzheimer’s Disease.  ACS Nano,      [PMID:38517764] [10.1021/acsnano.4c01206]

3. Liu Tonglinxi, Liu Wen, Li Xinyue, Wang Hanyu, Lan Yushan, Zhang Shengmin, Wang Yujun, Liu Huiqing.  (2024)  Effect of environmental factors on adsorption of ciprofloxacin from wastewater by microwave alkali modified fly ash.  Scientific Reports,  14  (1): (1-13).  [PMID:39215074] [10.1038/s41598-024-70921-6]

4. Runlin Han, Faxiang Feng, Zanming Zhu, Shi Su, Jingjing Wang, Chuxuan Shi, Guilin Dong, Hongbo Gu.  (2025)  Innovative bi-functional cellulose acetate/BiOCl photocatalytic membrane with excellent antibiotics degradation and photoresponsive antimicrobial performance.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.138959]

5. Longjie Xiao, Hongkui Zhang, Xue Song, Yongde Liu, Jie Zhang, Feiyue Wang, Guihua Yan, Han Zhang, Tianzeng Jin, Jihong Zhao.  (2025)  Competitive adsorption of oxytetracycline and ciprofloxacin on K2CO3-activated sycamore flocculent biochar.  MATERIALS CHEMISTRY AND PHYSICS,      [PMID:] [10.1016/j.matchemphys.2025.131899]

6. Faxiang Feng, Zanming Zhu, Jiale Li, Shi Su, Guilin Dong, Guanhui Wang, Xiaobing Liu, Runlin Han.  (2025)  In-situ grown electrospun PI/BiOCl nanofiber membranes for efficient photocatalytic degradation of antibiotics.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,      [PMID:] [10.1016/j.jphotochem.2025.117014]

7. Silin Li, Wenjie Zheng, Wenlan Ji, Yunfei Shi, Tian Ren, Shihao Zhang, Xiao Wei, Yibin Wei.  (2025)  Engineering of catalytic Ce@SiC ceramic membranes with ozonation for efficient antibiotic degradation.  DESALINATION,      [PMID:] [10.1016/j.desal.2025.119815]