Cyclopiazonic acid from Penicillium grisefulvum - ≥98% , CAS No.18172-33-3

CAS: 18172-33-3 Cat. No.: C276576 Molecular Weight: 336.38 EC Number: 634-041-6

GRADE & PURITY ≥98%

Synonyms

NSC 117181，(6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one，

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.

Product Application

Cyclopiazonic acid from Penicillium cyclopium has been used:
as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)
as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+ during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA

Specifications

Synonyms

NSC 117181，(6aS, 11aR, 11bR)-10-acetyl-11-hydroxy-7, 7-dimethyl-6a, 7, 11a, 11b-tetrahydro-2H-pyrrolo[1', 2':2, 3]isoindolo[4, 5, 6-cd]indol-9(6H)-one，

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase.Inhibits the sarcoplasmic reticulum Ca2+-pump.

Storage

Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• WGK Germany: 3
• RTECS: UY8587000
• UN Number: UN 2811
• Packing Group: II
• Molecular Weight: 336.38

Chemical and Physical Properties

• Solubility: DMSO: soluble;chloroform: soluble