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· · COA & SDS available for every product · Same-day shipping on in-stock items Daprodustat (GSK1278863) - Moligand™, ≥99% , Hypoxia-inducible factor prolyl hydroxylase inhibitor, CAS No.960539-70-2, Hypoxia-inducible factor prolyl hydroxylase inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99% Synonyms
2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinan-5-yl)formamido]acetic acid | Daprodustat | DTXSID501337360 | GTPL8455 | 4-[(1S)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol | Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)- | D
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
Daprodustat (GSK1278863) Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase ( HIF-PH ) inhibitor. Phase 2.
Targets
HIF-PH
In vitro
GSK1278863 induces an effective EPO response and stimulates non-EPO mechanisms for erythropoiesis.
Specifications Synonyms
2-[(1, 3-dicyclohexyl-2, 4, 6-trioxo-1, 3-diazinan-5-yl)formamido]acetic acid | Daprodustat | DTXSID501337360 | GTPL8455 | 4-[(1S)-1-hydroxy-2-methylaminoethyl]benzene-1, 2-diol | Glycine, N-((1, 3-dicyclohexylhexahydro-2, 4, 6-trioxo-5-pyrimidinyl)carbonyl)- | D
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Hypoxia-inducible factor prolyl hydroxylase inhibitor
Product Properties ALogP 1.747 hba_count 5 HBD Count 1 Rotatable Bond 5
Names and Identifiers Pubchem Sid 504772627 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772627 Canonical Smiles C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O IUPAC Name 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid InChIKey RUEYEZADQJCKGV-UHFFFAOYSA-N INCHI 1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24) Isomeric SMILES C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O Molecular Weight 393.43 Reaxy-Rn 29787380 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29787380&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives - N-acyl-alpha amino acids and derivatives Direct Parent N-acyl-alpha amino acids Alternative Parents Barbituric acid derivatives N-acyl ureas Diazinanes 1,3-dicarbonyl compounds Dicarboximides Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aliphatic heteromonocyclic compounds Substituents N-acyl-alpha-amino acid - Barbiturate - N-acyl urea - Pyrimidone - Ureide - 1,3-diazinane - Pyrimidine - 1,3-dicarbonyl compound - Dicarboximide - Urea - Secondary carboxylic acid amide - Carboxamide group - Carbonic acid derivative - Azacycle - Organoheterocyclic compound - Carboxylic acid - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organopnictogen compound - Organic oxide - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organic nitrogen compound - Aliphatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 20 mg/mL warmed with 50ºC Water: bath (50.83 mM); Water: Insoluble; Ethanol: Insoluble; DMSO(mg / mL) Max Solubility 10 DMSO(mM) Max Solubility 25.41748214 Water(mg / mL) Max Solubility ＜1 Molecular Weight 393.400 g/mol XLogP3 2.500 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 5 Exact Mass 393.19 Da Monoisotopic Mass 393.19 Da Topological Polar Surface Area 124.000 Ų Heavy Atom Count 28 Formal Charge 0 Complexity 627.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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