This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
Cromolyn disodium salt blocks the release of pro-inflammatory mediators, such as histamine, from mast cells.Reversible alveolar macrophage blocker and mast cell stabilizer. Anti-asthmatic and anti-inflammatory agent. Orally active. Active in vivo and in v
Storage
Argon charged, Room temperature
Shipped In
Normal
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as chromones. These are compounds containing a benzopyran-4-one moiety.
External Descriptors
organic sodium salt
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Soluble in water (100 mg/ml), DMSO (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Sensitivity
Moisture sensitive
Molecular Weight
512.299 g/mol
XLogP3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Rotatable Bond Count
6
Exact Mass
512.033 Da
Monoisotopic Mass
512.033 Da
Topological Polar Surface Area
172.000 Ų
Heavy Atom Count
36
Formal Charge
0
Complexity
824.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
3
References
1.Mingkang Zhang, Ruirui Cui, Yan Zhou, Yanrong Ma, Yongwen Jin, Lina Wang, Wen Kou, Xin’an Wu. (2023) Accumulation of Renal Fibrosis in Hyperuricemia Rats Is Attributed to the Recruitment of Mast Cells, Activation of the TGF-β1/Smad2/3 Pathway, and Aggravation of Oxidative Stress. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13):(10839). [PMID:37446016][10.3390/ijms241310839]
2.Lei Wang, Anduo Zhou, Chongshuai Chen, Xia Huang, Shanfeng Zhang, Junying Chen. (2023) Preparation and properties of composite hydrogels for 3D bioprinting. POLYMERS FOR ADVANCED TECHNOLOGIES, 34 (7):(2369-2383). [PMID:][10.1002/pat.6057]
3.Mingkang Zhang, Ruirui Cui, Yan Zhou, Yanrong Ma, Yongwen Jin, Xueyan Gou, Jinru Yang, Xin’an Wu. (2022) Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. TOXICOLOGY, [PMID:36464070][10.1016/j.tox.2022.153387]
4.Xiaojun Zhang, Wensi Wu, Zhenzhen Zheng, Liang Li, Junjun Chen, Junying Zhong, Le Zhao, Jiawei Chen, Zhi Wang, Fanqing Meng. (2022) Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice. Frontiers in Neuroscience, [PMID:36188474][10.3389/fnins.2022.990333]
6.Jun Zhang, Qingmei Liu, Fudie Gu, Yan Li, Huiying Chen, Meng Liu, Yu Zhou, Hong Liu, Xiaofeng Wei, Guangming Liu. (2024) In vivo evaluations of Lactobacillus-fermented Eucheuma spinosum polysaccharides on alleviating food allergy activity. Food & Function, 15 (11):(5895-5907). [PMID:38727519][10.1039/D4FO00991F]
7.Mingkang Zhang, Jinru Yang, Yufan Yuan, Yan Zhou, Yazhi Wang, Ruirui Cui, Yimai Maliu, Fen Xu, Xin’an Wu. (2024) Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride-induced liver injury. MOLECULAR IMMUNOLOGY, [PMID:38626622][10.1016/j.molimm.2024.04.009]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
Reviews
Customer Reviews
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our Cookie Policy.
Shall we send you a message when we have discounts available?
Remind me later
Thank you! Please check your email inbox to confirm.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
A2604072