Racemic efonidipine has both L-type and T-type calcium channel protein inhibitor activity. The R(?)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.
| Pubchem Sid | 488188359 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488188359 |
| Canonical Smiles | CCO.CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl |
| IUPAC Name | 2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;ethanol;hydrochloride |
| InChIKey | IKBJGZQVVVXCEQ-UHFFFAOYSA-N |
| INCHI | 1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H |
| Isomeric SMILES | CCO.CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl |
| Molecular Weight | 714.18 |
| Reaxy-Rn | 5902629 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5902629&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Pyridines and derivatives |
| Subclass | Hydropyridines |
| Intermediate Tree Nodes | Dihydropyridines |
| Direct Parent | Dihydropyridinecarboxylic acids and derivatives |
| Alternative Parents | Monocarboxylic acids and derivatives Primary alcohols Organic zwitterions Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Not available |
| Substituents | Dihydropyridinecarboxylic acid derivative - Monocarboxylic acid or derivatives - Organic oxygen compound - Hydrocarbon derivative - Hydrochloride - Organic zwitterion - Primary alcohol - Organooxygen compound - Alcohol - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 A23311312 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311311 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311308 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311307 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311306 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311299 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311295 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311281 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311278 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311238 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311135 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| A23311124 | Certificate of Analysis | Nov 06, 2025 | E336166 |
| C2525468 | Certificate of Analysis | Nov 01, 2022 | E336166 |
| Solubility | >5 mg/mL in DMSO |
|---|---|
| Sensitivity | Moisture sensitive. |
| Molecular Weight | 714.200 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 10 |
| Exact Mass | 713.263 Da |
| Monoisotopic Mass | 713.263 Da |
| Topological Polar Surface Area | 143.000 Ų |
| Heavy Atom Count | 49 |
| Formal Charge | 0 |
| Complexity | 1170.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 3 |
