Endothelin 3 human, rat (TFA) - ≥95% , Agonist of ET B receptor, CAS No.117399-93-6(free basis), Agonist of ET B receptor

CAS: 117399-93-6(free basis) Cat. No.: E118811 Molecular Weight: 2757.07(free basis) EC Number: 687-672-4

GRADE & PURITY ≥95%

Synonyms

ET-3 | Endothelin 3 (Rat,Human)

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.

Application：

Endothelin 3 has also been used as a ligand for endothelin receptor type B (EDNRB) in ex vivo enteric NCC (eNCC) migration assays. Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.

Specifications

Synonyms

ET-3 | Endothelin 3 (Rat, Human)

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intest

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Agonist of ET B receptor

Note

In order to achieve better dissolution, please heat the test tube at 37 ℃ and shake it for a moment in an ultrasonic water bath. The solubility of products from different manufacturers and batches varies, and is for reference only. If the concentration required for the experiment is too high to the product dissolution limit, please add a solubilizer or adjust the concentration yourself. The solution form is generally not suitable for long-term storage. Please use it up as soon as possible.

Purity

≥95%

Names and Identifiers

• Molecular Weight: 2757.07(free basis)

Associated Targets(Human)

EDNRB Tclin Endothelin receptor type B (0 Activities)

Discover Target: EDNRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Soluble to 1 mg/ml in Water
• Sensitivity: moisture sensitive