1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Cell membrane microdomains are jointly organized by specific lipids, scaffold proteins, and the cytoskeleton. They can restrict membrane protein diffusion and regulate ion channels, transporters, receptor signaling, and vesicular trafficking. Abnormalities in membrane microdomain composition ...
Monkeypox virus can form mature virions and enveloped virions. Different surface antigens participate in viral attachment, membrane fusion, and cell-to-cell spread and are also important targets for nucleic acid detection, immunodiagnosis, vaccine design, and antiviral drug research.
Capryloyl salicylic acid is a derivative of salicylic acid produced through lipophilic structural modification. It retains the o-hydroxybenzoic acid structure while introducing an octanoyl group at the 5-position of the benzene ring, thereby altering the molecule’s lipid affinity, molecular ...
The benzene ring can restrict molecular conformation, control substituent orientation, and participate in target binding through hydrophobic interactions, π–π interactions, or cation–π interactions. It is therefore widely present in drug molecules. However, in some lead compounds, ...
Metabolic dysfunction-associated steatohepatitis is jointly driven by hepatic fat accumulation, lipotoxicity, insulin resistance, inflammation, and fibrosis. Targeting lipid metabolism, nuclear receptors, incretin pathways, and FGF signaling has become a major direction in drug development.
Carbonic anhydrases maintain tissue acid-base balance and gas transport by catalyzing the reversible conversion of carbon dioxide and bicarbonate. Abnormal expression of different isoenzymes can contribute to tumor acidification, glaucoma, abnormal neuronal excitability, and metabolic disorders.
This article primarily refers to the study by Badland et al., entitled “A comparative study of amide-bond forming reagents in aqueous media—Substrate scope and reagent compatibility,” published in Tetrahedron Letters.
TL1A amplifies Th1/Th17 immune responses through DR3 and participates in intestinal mucosal inflammation, synovial injury, psoriatic lesions, and intestinal wall fibrosis. It has become an important target for autoimmune disease mechanism research and antibody drug development.
Proteolysis-targeting chimeras (PROTACs) are a class of heterobifunctional molecules that selectively reduce the abundance of a protein of interest by harnessing the cellular ubiquitin–proteasome system (UPS). They represent an important modality within the field of targeted protein ...
