Fatostatin - 10mM in DMSO , CAS No.125256-00-0

CAS: 125256-00-0 Cat. No.: F421056 Molecular Weight: 294.41 EC Number: 682-929-7

GRADE & PURITY 10mM in DMSO

Synonyms

2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole | Fatostatin;125B11 | BCP20994 | cid_2850562 | 2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole | 4-(4-METHYLPHENYL)-2-(2-PROPYL-4-PYRIDYL)-1,3-TH

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Fatostatin Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

Targets

SREBP

In vitro

Fatostatin impairs the activation process of sterol regulatory element binding proteins (SREBPs), thereby decreasing the transcription of lipogenic genes in cells. Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain.

In vivo

Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin may serve as a tool for gaining further insights into the regulation of SREBP.

Cell Research(from reference)

Cell lines：CHO-K1 cells 

Concentrations：20 μM 

Incubation Time：20 h 

Specifications

Synonyms

2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole | Fatostatin;125B11 | BCP20994 | cid_2850562 | 2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1, 3-thiazole | 4-(4-METHYLPHENYL)-2-(2-PROPYL-4-PYRIDYL)-1, 3-TH

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. F

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• ALogP: 4.898
• hba_count: 2
• Rotatable Bond: 4

Names and Identifiers

• Canonical Smiles: CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C
• IUPAC Name: 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
• InChIKey: ZROSUBKIGBSZCG-UHFFFAOYSA-N
• INCHI: 1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
• Isomeric SMILES: CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C
• Molecular Weight: 294.41
• Reaxy-Rn: 18507978
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18507978&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azoles
      • Subclass Thiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azoles
• Subclass: Thiazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: 2,4-disubstituted thiazoles
• Alternative Parents: Toluenes Pyridines and derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Toluene - 2,4-disubstituted 1,3-thiazole - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Mycobacterium tuberculosis (203094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 75
• DMSO(mM) Max Solubility: 254.746781698991
• Water(mg / mL) Max Solubility: ＜1
• Molecular Weight: 294.400 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 294.119 Da
• Monoisotopic Mass: 294.119 Da
• Topological Polar Surface Area: 54.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 314.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui.  (2023)  Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37870273] [10.1021/acs.jafc.3c01244]

2. Yu Su, Haobo Wen, Ke Hu, Cuiping Wen, Ping Wang, Lulu Zhao, Gang Zou, Wei Jiang, Yaxi Chen, Yunfei Zhao, Qiu Li.  (2026)  An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41866523] [10.1186/s12951-026-04301-9]

3. Li Yitao, Zheng Weijia, Ma Jiao, Liu Lu, Yang Xintong, Kuang Junliang, Chan Nickie, Wang Chengqiang, Li Yang, Zhao Aihua, Wang Ruonan, Zheng Xiaojiao, Melino Gerry, Lu Aiping, Yang Xiaolu, Jia Wei.  (2026)  Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis.  CELL DEATH AND DIFFERENTIATION,      [PMID:] [10.1038/s41418-026-01696-8]