FKGK18 - Moligand™,≥99% , CAS No.1071001-09-6

CAS: 1071001-09-6 Cat. No.: F649923 Molecular Weight: 280.28

GRADE & PURITY Moligand™, ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

FKGK18 is a selective group VIA calcium-independent phospholipase A 2 (GVIA iPLA 2 ) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC 50 s of 50 nM and 3 μM for iPLA 2 β and iPLA 2 γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes

In Vitro

FKGK18 (1 nM; 1 h) inhibits glucose-stimulated insulin secretion (GSIS) and prostaglandin E2 (PGE2) generation. FKGK18 (0.1-10 nM; 24 h) inhibits beta-cell apoptosis. FKGK18 (0.1-10 μM; 24 h) affects immune cells function and influences B-cell survival. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human pancreatic islets Concentration: 1 nM Incubation Time: 1 h Result: Inhibited GSIS from pancreatic islets, AA hydrolysis from beta-cells membranes and PGE2 generation. Penetrated islets and the beta-cells from islets. Apoptosis AnalysisCell Line: INS-1 OE cells Concentration: 0.1-10 nM Incubation Time: 24 h Result: Inhibited beta-cells apoptosis induced by ER-stress. Cell Viability AssayCell Line: CD4 + T-cell and B-cell from 8–12-week-old NOD female mice Concentration: 0.1-10 μM/L Incubation Time: 24 h Result: Decreased TNF-α generation, reduced viability of B cell and antibody production.

In Vivo

FKGK18 (20 mg/kg; i.p. three times per week from 10 days until euthanasia) reduces diabetes incidence. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 10-day-old female NOD miceDosage: 20 mg/kg Administration: Intraperitoneal injection; 20 mg/kg three times per week; from 10 days until euthanasia Result: Reduced diabetes incidence and maintained better glucose homeostasis.

Form:Solid

IC50& Target:IC50: 50 nM (iPLA2β), 3 μM (iPLA2γ)

Specifications

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

FKGK18 is a selective group VIA calcium-independent phospholipase A 2 (GVIA iPLA 2 ) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC 50 s of 50 nM and 3 μM for iPLA 2 β and iPLA 2 γ. FKGK18 can be used for the research of beta-cell apoptos

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1=CC=C2C=C(C=CC2=C1)CCCCC(=O)C(F)(F)F
• IUPAC Name: 1,1,1-trifluoro-6-naphthalen-2-ylhexan-2-one
• InChIKey: VCWWTQMRNJSJGC-UHFFFAOYSA-N
• INCHI: 1S/C16H15F3O/c17-16(18,19)15(20)8-4-1-5-12-9-10-13-6-2-3-7-14(13)11-12/h2-3,6-7,9-11H,1,4-5,8H2
• Isomeric SMILES: C1=CC=C2C=C(C=CC2=C1)CCCCC(=O)C(F)(F)F
• Molecular Weight: 280.28

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Naphthalenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Naphthalenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenes
• Alternative Parents: Alpha-haloketones Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Naphthalene - Alpha-haloketone - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organofluoride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl fluoride - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PLA2G4A Tchem Cytosolic phospholipase A2 (785 Activities)

Discover Target: PLA2G4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLA2G6 Tchem Calcium-independent phospholipase A2 (359 Activities)

Discover Target: PLA2G6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLA2G5 Tchem Phospholipase A2 group V (238 Activities)

Discover Target: PLA2G5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 280.280 g/mol
• XLogP3: 5.500
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 280.107 Da
• Monoisotopic Mass: 280.107 Da
• Topological Polar Surface Area: 17.100 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 324.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1