10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 14 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Flumequine is a synthetic chemotherapeutic antibiotic, inhibitingtopoisomerase IIwithIC50of 15 μM.
In vitro
Flumequine inhibits eukaryotic topoisomerase II, which is responsible for the double-strand DNA breakage reaction as well as bacterial gyrase, inhibitory effects of FL on topoisomerase II are high relative to the influence on bacterial gyrase. Flumequine has minimum inhibitory concentration (MIC) ranging from 0.06 μg/mL to 32 μg/mL in 12 clinical A. salmonicida isolates. Flumequine enhibits high E(max) values of 16 for the most resistant isolates, which indicates an important contribution of efflux to the resistance phenotype. Flumequine accumulation experiments confirmes that high E(max) values are associated with a much lower level of accumulation.
In vivo
Flumequine (4000 ppm, oral diet) induces dose-dependent DNA damage in the stomach, colon, and urinary bladder of adult mice at 3 hours but not at 24 hours after its administration. Flumequine shows the bioavailability of 44.7% following oral administration of medicated feed in Atlantic salmon. Flumequine results in the volumes of distribution at steady state of 3.5 L/kg, elimination half-life (t 1/2) of 22.8 hours and area under plasma drug concentration-time curve (AUC) of 140 μg×hours/mL following intravenous administration in Atlantic salmon. Flumequine (100 mg/L) reduces the mean length of root, hypocotyle, cotyledon and the mean number of secondary roots in aquatic weed Lythrum salicaria L. Flumequine (10 mg/kg, oral) results in the volumes of distribution at steady-state (Vss) of 2.41 L/kg (cod) and 2.15 L/kg (wrasse) following intravenous administration. Total body clearances (Cl) are 0.024 L/h.kg (cod) and 0.14 L/h.kg (wrasse) and the elimination half-lives (t1/2 λ z) are calculated to be 75 hours (cod) and 31 hours (wrasse) after Flumequine (10 mg/kg, oral) administration. The oral bioavailabilities (F) are calculated to be 65% (cod) and 41% (wrasse) following oral administration of Flumequine.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O |
|---|---|
| Molecular Weight | 261.25 |
| Reaxy-Rn | 490724 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=490724&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 6 mg/mL (25.83 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Melt Point(°C) | 259 °C |
| 1. Xiaoyi Pu, Xin Wang, Youping Liu, Xin Di. (2023) A novel deep eutectic solvent-based ultrasound-assisted dispersive liquid–liquid microextraction coupled with high-performance liquid chromatography for the determination of quinolones in environmental water samples. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2023.109374] |
| 2. Yifan Wu, Xiaoxia Gong, Jianzhong Shen, Kui Zhu. (2023) Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages. Journal of Advanced Research, [PMID:37290606] [10.1016/j.jare.2023.05.010] |
| 3. Yuanjie Teng, Zhenni Wang, Shaohua Zuo, Xin Li, Yinxin Chen. (2022) Identification of antibiotic residues in aquatic products with surface-enhanced Raman scattering powered by 1-D convolutional neural networks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:36549071] [10.1016/j.saa.2022.122195] |
| 4. Boqiang Gao, Yu Pan, Hu Yang. (2022) Enhanced photo-Fenton degradation of fluoroquinolones in water assisted by a 3D composite sponge complexed with a S-scheme MoS2/Bi2S3/BiVO4 ternary photocatalyst. APPLIED CATALYSIS B-ENVIRONMENTAL, [PMID:] [10.1016/j.apcatb.2022.121580] |
| 5. Boqiang Gao, Yu Pan, Qianqian Chang, Zhonghua Xi, Hu Yang. (2022) Hierarchically Z-scheme photocatalyst of {0 1 0}BiVO4/Ag/CdS with enhanced performance in synergistic adsorption-photodegradation of fluoroquinolones in water. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.134834] |
| 6. Zhe Zhao, Bolong Liang, Menglu Wang, Qi Yang, Ming Su, Shu-xuan Liang. (2021) Microporous carbon derived from hydroxyl functionalized organic network for efficient adsorption of flumequine: Adsorption mechanism and application potentials. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.130943] |
| 7. Li Jianwen, Huang Xiangjin, Ma Jinkui, Wei Shoulian, Zhang Huasheng. (2020) A novel electrochemical sensor based on molecularly imprinted polymer with binary functional monomers at Fe-doped porous carbon decorated Au electrode for the sensitive detection of lomefloxacin. IONICS, 26 (8): (4183-4192). [PMID:] [10.1007/s11581-020-03554-0] |
| 8. Sandip Mondal, Jianqiao Xu, Guosheng Chen, Siming Huang, Chuyu Huang, Li Yin, Gangfeng Ouyang. (2018) Solid-phase microextraction of antibiotics from fish muscle by using MIL-101(Cr)NH2-polyacrylonitrile fiber and their identification by liquid chromatography-tandem mass spectrometry. ANALYTICA CHIMICA ACTA, [PMID:30567665] [10.1016/j.aca.2018.09.060] |
| 9. Fengliang Wang, Yiping Feng, Ping Chen, Yingfei Wang, Yuehan Su, Qianxin Zhang, Yongqin Zeng, Zhijie Xie, Haijin Liu, Yang Liu, Wenying Lv, Guoguang Liu. (2018) Photocatalytic degradation of fluoroquinolone antibiotics using ordered mesoporous g-C3N4 under simulated sunlight irradiation: Kinetics, mechanism, and antibacterial activity elimination. APPLIED CATALYSIS B-ENVIRONMENTAL, [PMID:] [10.1016/j.apcatb.2018.01.024] |
| 10. Yijia Tang, Jianqiao Xu, Le Chen, Junlang Qiu, Yuan Liu, Gangfeng Ouyang. (2017) Rapid in vivo determination of fluoroquinolones in cultured puffer fish (Takifugu obscurus) muscle by solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry. TALANTA, [PMID:28842032] [10.1016/j.talanta.2017.07.066] |
| 11. Xiangwen Chen, Xuan Chen, Juan Pan, Shuqi Deng, Qiubing Qin, Qiang Fu, Jiliang Cao. (2025) Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism. CHIRALITY, 37 (8): (e70050). [PMID:40678879] [10.1002/chir.70050] |
| 12. Jintao Yi, Nani Fu, Anqi Li, Ping Yan, Hui Pan, Xiulong Deng, Jun Xue, Xun Li. (2025) Fluorescent Determination of Flumequine Using a Novel Tryptophan (Trp)—Zeolitic Imidazolate Framework-8 (ZIF-8)—Terbium (III) Visual Probe. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2025.2530052] |
| 13. Shuyuan Guo, Miao Liu, Hanlin Liu, Jingru Mao, Yongfeng Zou, Li-Peng Sun, Yan Huang, Dandan Sun, Jie Ma. (2025) A reflective microfiber biosensor for monitoring of trace flumequine residues enhanced by europium-incorporated covalent organic framework. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.114929] |
| 14. Boqiang Gao, Koukou Tao, Zhonghua Xi, Mayyada M.H. El-Sayed, Tamer Shoeib, Hu Yang. (2022) Fabrication of 3D lignosulfonate composited sponges impregnated by BiVO4/polyaniline/Ag ternary photocatalyst for synergistic adsorption-photodegradation of fluoroquinolones in water. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.137282] |
