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· · COA & SDS available for every product · Same-day shipping on in-stock items GDC-0326 - ≥98% , CAS No.1282514-88-8
Synonyms
SCHEMBL1485471 | AKOS030621797 | A901393 | (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide | (25)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-y
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
GDC-0326 is a potent and selective inhibitor ofPI3Kαwith Ki value of 0.2 nM; remarkably selective over the other class I isoforms in enzymatic assays.
Targets
PI3Kα (Cell-free assay); PI3Kδ (Cell-free assay); PI3Kγ (Cell-free assay); PI3Kβ (Cell-free assay) 0.2 nM(Ki); 4 nM(Ki) ;10.2 nM(Ki); 26.6 nM(Ki)
In vitro
In addition to achieving selectivity over the other class I isoforms, the PI3Kα specific inhibitor GDC-0326 also achieves a very high level of selectivity over other kinases. GDC-0326 is not an inhibitor of cytochrome P450 enzymes tested.
In vivo
GDC-0326 has consistently low clearance and high oral bioavailability across species tested, enabling significant sustained free drug levels.
Cell Research(from reference)
Cell lines：βTC3 cells
Concentrations：1 μM
Incubation Time：2 h
Specifications Synonyms
SCHEMBL1485471 | AKOS030621797 | A901393 | (S)-2-((2-(1-isopropyl-1H-1, 2, 4-triazol-5-yl)-5, 6-dihydrobenzo[f]imidazo[1, 2-d][1, 4]oxazepin-9-yl)oxy)propanamide | (25)-2-(2-(1-isopropyl-1H-1, 2, 4-triazol-5-yl)-5, 6-dihydrobenzo[f]imidazo[1, 2-d][1, 4]oxazepin-9-y
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
GDC-0326 is a potent and selective inhibitor of PI3Kα with Ki value of 0.2 nM; remarkably selective over the other class I isoforms in enzymatic assays.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Properties ALogP 2.017 HBD Count 1 Rotatable Bond 5
Names and Identifiers Pubchem Sid 504771665 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771665 Canonical Smiles CC(C)N1C(=NC=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)OC(C)C(=O)N IUPAC Name (2S)-2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide InChIKey SIKYDKLGPWRPMZ-LBPRGKRZSA-N INCHI 1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1 Isomeric SMILES C[C@@H](C(=O)N)OC1=CC2=C(C=C1)C3=NC(=CN3CCO2)C4=NC=NN4C(C)C PubChem CID 58204997 Molecular Weight 382.42
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Phenol ethers Subclass Not available Intermediate Tree Nodes Not available Direct Parent Phenol ethers Alternative Parents Alkyl aryl ethers N-substituted imidazoles Triazoles Heteroaromatic compounds Primary carboxylic acid amides Oxacyclic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Phenol ether - Alkyl aryl ether - N-substituted imidazole - Azole - Imidazole - Heteroaromatic compound - 1,2,4-triazole - Carboxamide group - Primary carboxylic acid amide - Carboxylic acid derivative - Ether - Oxacycle - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organic oxide - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 76 mg/mL (198.73 mM); Ethanol: 19 mg/mL (49.68 mM); Water: Insoluble; DMSO(mg / mL) Max Solubility 76 DMSO(mM) Max Solubility 198.7343758 Water(mg / mL) Max Solubility ＜1 Molecular Weight 382.400 g/mol XLogP3 1.200 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 5 Exact Mass 382.175 Da Monoisotopic Mass 382.175 Da Topological Polar Surface Area 110.000 Ų Heavy Atom Count 28 Formal Charge 0 Complexity 564.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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