Ginsenoside-Rb1 - 10mM in DMSO , CAS No.41753-43-9

CAS: 41753-43-9 Cat. No.: G423890 Molecular Weight: 1109.29 EC Number: 255-532-8

GRADE & PURITY 10mM in DMSO

Synonyms

5-25-10-00493 (Beilstein Handbook Reference) | AKOS025311537 | BDBM50317541 | Ginsenoside rb1 | Gypenoside III | GinsenosideRb1 | ginsenoside-Rb1 | MFCD00133367 | s3924 | CHEBI:67989 | AC-2261 | (3beta,12beta)-20-((6-O-(beta-D-glucopyranosyl)-beta-D-gluco

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyms

5-25-10-00493 (Beilstein Handbook Reference) | AKOS025311537 | BDBM50317541 | Ginsenoside rb1 | Gypenoside III | GinsenosideRb1 | ginsenoside-Rb1 | MFCD00133367 | s3924 | CHEBI:67989 | AC-2261 | (3beta, 12beta)-20-((6-O-(beta-D-glucopyranosyl)-beta-D-gluco

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Natural triterpenoid saponin with variety of biological activities. Shown to promote adipogenesis. Active in vitro and in vivo .

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C
• IUPAC Name: (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• InChIKey: GZYPWOGIYAIIPV-JBDTYSNRSA-N
• INCHI: 1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1
• Isomeric SMILES: CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C
• WGK Germany: 3
• RTECS: LZ5856000
• Molecular Weight: 1109.29
• Reaxy-Rn: 11334160
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11334160&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Prenol lipids
      • Subclass Terpene glycosides
        • Level5 Triterpene glycosides
          • Level6 Triterpene saponins

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Prenol lipids
• Subclass: Terpene glycosides
• Intermediate Tree Nodes: Triterpene glycosides
• Direct Parent: Triterpene saponins
• Alternative Parents: Triterpenoids Steroidal glycosides 12-hydroxysteroids 14-alpha-methylsteroids Fatty acyl glycosides of mono- and disaccharides Alkyl glycosides Disaccharides O-glycosyl compounds Oxanes Secondary alcohols Cyclic alcohols and derivatives Polyols Acetals Oxacyclic compounds Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Triterpene saponin - Triterpenoid - Steroidal glycoside - 12-hydroxysteroid - 14-alpha-methylsteroid - Hydroxysteroid - Steroid - Fatty acyl glycoside - Fatty acyl glycoside of mono- or disaccharide - Alkyl glycoside - Disaccharide - Glycosyl compound - O-glycosyl compound - Fatty acyl - Oxane - Cyclic alcohol - Secondary alcohol - Polyol - Acetal - Organoheterocyclic compound - Oxacycle - Hydrocarbon derivative - Organic oxygen compound - Alcohol - Primary alcohol - Organooxygen compound - Aliphatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as triterpene saponins. These are glycosylated derivatives of triterpene sapogenins. The sapogenin moiety backbone is usually based on the oleanane, ursane, taraxastane, bauerane, lanostane, lupeol, lupane, dammarane, cycloartane, friedelane, hopane, 9b,19-cyclo-lanostane, cycloartane, or cycloartanol skeleton.
• External Descriptors: glycoside - tetracyclic triterpenoid - ginsenoside

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TOP1 Tclin DNA topoisomerase I (7553 Activities)

Discover Target: TOP1

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TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)

Discover Target: TOP2A

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DU-145 (51482 Activities)

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HCT-8 (3484 Activities)

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HL-60 (67320 Activities)

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PANC-1 (6144 Activities)

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PC-3 (62116 Activities)

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SK-N-SH (1499 Activities)

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U-251 (51189 Activities)

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A549 (127892 Activities)

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KB (17409 Activities)

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

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Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)

Discover Target: pol

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Mus musculus (284745 Activities)

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B16 (5829 Activities)

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C6 (2371 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 1109.300 g/mol
• XLogP3: 0.300
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 23
• Rotatable Bond Count: 16
• Exact Mass: 1108.6 Da
• Monoisotopic Mass: 1108.6 Da
• Topological Polar Surface Area: 377.000 Ų
• Heavy Atom Count: 77
• Formal Charge: 0
• Complexity: 2000.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 30
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Chengxian Wang, Xingling Zhao, Qiumin Li, Jianfeng Liu, Chengyue Liang, Changmei Wang, Bin Yang, Kai Wu, Fang Yin, Wudi Zhang.  (2023)  Anaerobic digestion for degrading saponins from Panax notoginseng root and applying biogas slurry to promote degradation of autotoxic saponins in continuous cropping soil.  Environmental Technology & Innovation,      [PMID:] [10.1016/j.eti.2023.103203]

2. Wen Shan, Zou Zhi-Ru, Cheng Shuai, Guo Hui, Hu Heng-Shuo, Zeng Fan-Zhuo, Mei Xi-Fan.  (2022)  Ginsenoside Rb1 improves energy metabolism after spinal cord injury.  Neural Regeneration Research,  18  (6): (1332).  [PMID:36453420] [10.4103/1673-5374.357915]

3. Mengmeng Zheng, Wenxiu Zheng, Wei Wang, Hong Guo, Hui Cao, Xiaowei Cui, Shanshan Wang, Chunchao Han.  (2019)  Study on the Effect of Ginsenosides Rb on Blood of Tumor Mice.  Biomed Research International,      [PMID:31531357] [10.1155/2019/5476076]

4. Shuai Ji, Xian Shao, Zhen-yu Su, Lei Ji, Yu-jie Wang, Yun-su Ma, Lu Zhao, Yan Du, Meng-zhe Guo, Dao-quan Tang.  (2019)  Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:31202879] [10.1016/j.jpba.2019.05.055]

5. Nan Zhao, Mengchun Cheng, Shuai Huang, Dan Liu, Qiang Zhao, Yunpeng Bai, Xiaozhe Zhang.  (2019)  Various Multicharged Anions of Ginsenosides in Negative Electrospray Ionization with QTOF High-Resolution Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:30644055] [10.1007/s13361-018-2089-5]

6. Jiahong Han, Min Dai, Yan Zhao, Enbo Cai, Lianxue Zhang, Xiaohuan Jia, Nian Sun, Xuan Fei, Hui Shu.  (2019)  Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis.  Journal of Ginseng Research,      [PMID:32148411] [10.1016/j.jgr.2019.01.001]

7. Zhi Zheng, Jian Sun, Jun Wang, Suisui He, Zhenqiu Liu, Jiahao Xie, Cui-Yun Yu, Hua Wei.  (2024)  Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation.  JOURNAL OF CONTROLLED RELEASE,      [PMID:38852624] [10.1016/j.jconrel.2024.06.015]

8. Qing Zheng, Feng-Ping Lei, Shan Hui, Ming Tong, Li-Hui Liang.  (2024)  Ginsenoside Rb1 Relieves Cellular Senescence and Pulmonary Fibrosis by Promoting NRF2/QKI/SMAD7 Axis.  AMERICAN JOURNAL OF CHINESE MEDICINE,      [PMID:39756830] [10.1142/S0192415X24500952]

9. Shuanglin Deng, Fang Wang, Meng Xiong, Bangxing Han, Hui Yan.  (2024)  Rapid on-site multi-indicator detection of Polygonatum cyrtonema Hua by handheld near-infrared spectroscopy with wavelength selection.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111920]

10. Wei Liangli, Yuan Yuqi, Yang Ziteng, Li Yuqing, Wang Tingting, Hu Shenglin, Cai Biao, Wang Guangyun.  (2024)  Ginsenoside Rb1 reduced ischemic stroke-induced apoptosis through endoplasmic reticulum stress-associated IRE1/TRAF2/JNK pathway.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:39052059] [10.1007/s00210-024-03292-4]

11. Yao Wang, Hua Dong-Ming, Wang Wen-kai, Zhang Zhao-zhou, Guan Yun-Feng, Wang Yan.  (2025)  Ginsenoside Rb1 inhibits chronic stress-induced colorectal cancer via regulating glycolysis and β2-AR/CREB1 signaling pathway.  JOURNAL OF PHARMACY AND PHARMACOLOGY,      [PMID:40498670] [10.1093/jpp/rgaf031]

12. Ruiquan Ding, Mengdie Li, Yawen Zhang, Hongyi Liu, Zhenyu Tang, Xiyue Xiong, Yingzhuang Chen, Ming Ma, Bo Chen.  (2025)  Paternò-Büchi Reaction-Mediated High-Selectivity Screening of Isoprene-Containing Naturals by LC-HRMS.  TALANTA,      [PMID:41240653] [10.1016/j.talanta.2025.129074]

13. Mengqiong Wang, Baifei Hu, Jimin Ni, Kun Liu, Shuanggui Tian, Junping Zheng, Songlin Liu, Hongtao Liu.  (2025)  Multi-omics joint analysis: Arctii Fructus extract alleviates functional constipation by modulating microbiota-host co-metabolism and suppressing NLRP3 inflammasome activation.  FOOD RESEARCH INTERNATIONAL,      [PMID:41539750] [10.1016/j.foodres.2025.118085]

14. Yali Yang, Hui Ding, Kaijun Quan, Hongwei Zhao, Mingxia Sun, Zhimin Yang, Xiuhui Liu, Hongdeng Qiu, Jia Chen.  (2026)  Pyrene trisulfonic acid-functionalized silica-based multi-mode stationary phase for separation of hydrophilic, hydrophobic compounds and rare earth ions.  ANALYTICA CHIMICA ACTA,      [PMID:41813355] [10.1016/j.aca.2026.345267]

15. Yue-qiang Chen, Xiao-xia Dong, Li Liu, Xiu-ping Chen, Chen-guo Feng, Li-xing Zhan, Yue Su, Fang Zhang, Yin-long Guo.  (2026)  Stable isotope labeling LC–MS for profiling the amine submetabolome in a D-lactate treated cell model.  ANALYTICA CHIMICA ACTA,      [PMID:] [10.1016/j.aca.2026.345649]