≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
GSK620 GSK620 is a pan- BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.
Targets
BD2
In vitro
GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 is capable of reducing the MCP-1 response in a concentration-dependent manner, providing strong evidence that GSK620 is indeed engaging BD2 in cells.
In vivo
GSK620 is a potent and selective pan-BD2 inhibitor with excellent in vivo PK properties and excellent developability properties, with the exception of moderate FaSSIF solubility driven by its highly crystalline nature.
Cell Research(from reference)
Cell lines：human whole blood, hepatocytes
Concentrations：0.5 μM
Incubation Time：60 min, 120 min
| ALogP | 0.291 |
|---|---|
| hba_count | 3 |
| HBD Count | 2 |
| Rotatable Bond | 5 |
| Pubchem Sid | 488202715 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202715 |
| Canonical Smiles | CNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3 |
| IUPAC Name | 1-benzyl-5-N-cyclopropyl-3-N-methyl-2-oxopyridine-3,5-dicarboxamide |
| InChIKey | QZZCUOVXHPAQRQ-UHFFFAOYSA-N |
| INCHI | 1S/C18H19N3O3/c1-19-17(23)15-9-13(16(22)20-14-7-8-14)11-21(18(15)24)10-12-5-3-2-4-6-12/h2-6,9,11,14H,7-8,10H2,1H3,(H,19,23)(H,20,22) |
| Isomeric SMILES | CNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3 |
| Molecular Weight | 325.36 |
| Reaxy-Rn | 31020658 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31020658&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Pyridines and derivatives |
| Subclass | Pyridinecarboxylic acids and derivatives |
| Intermediate Tree Nodes | Pyridinecarboxamides |
| Direct Parent | Nicotinamides |
| Alternative Parents | Pyridinones Dihydropyridines Benzene and substituted derivatives Vinylogous amides Heteroaromatic compounds Secondary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Nicotinamide - Pyridinone - Dihydropyridine - Benzenoid - Hydropyridine - Monocyclic benzene moiety - Heteroaromatic compound - Vinylogous amide - Secondary carboxylic acid amide - Lactam - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2308479 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308483 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308493 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308494 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308496 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308497 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308500 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308544 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308546 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308547 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308554 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308624 | Certificate of Analysis | Feb 05, 2026 | G414458 |
| E2308475 | Certificate of Analysis | Apr 03, 2023 | G414458 |
| Solubility | Solubility (25°C) In vitro DMSO: 65 mg/mL (199.77 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 65 |
| DMSO(mM) Max Solubility | 199.778706663388 |
| Water(mg / mL) Max Solubility | ＜1 |
| Molecular Weight | 325.400 g/mol |
| XLogP3 | 1.500 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 325.143 Da |
| Monoisotopic Mass | 325.143 Da |
| Topological Polar Surface Area | 78.500 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 599.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
