GW806742X hydrochloride - ≥98% , CAS No.G659343

CAS: G659343 Cat. No.: G659343 Molecular Weight: 610.01

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl

Appearance:Solid

IC50& Target:MLKL|9.3 μM (Kd)|VEGFR2|2 nM (IC|50|)

In Vitro:GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induce

Biological Activity:GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: [H]Cl.O=S(C1=CC=CC(NC2=NC=CC(N(C)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3)=N2)=C1)(N)=O
• Molecular Weight: 610.01

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (163.93 mM; Need ultrasonic) H2O : ＜ 0.1 mg/mL (ultrasonic) (insoluble)