≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration
| Canonical Smiles | C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O |
|---|---|
| IUPAC Name | N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide |
| InChIKey | ZIMKJLALTRLXJO-UHFFFAOYSA-N |
| INCHI | 1S/C16H19N3O3/c20-11-3-4-14-13(8-11)10(9-19-14)5-7-18-16(22)12-2-1-6-17-15(12)21/h3-4,8-9,12,19-20H,1-2,5-7H2,(H,17,21)(H,18,22) |
| Isomeric SMILES | C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O |
| Molecular Weight | 301.34 |
| Reaxy-Rn | 26247052 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26247052&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Indoles and derivatives |
| Subclass | Tryptamines and derivatives |
| Intermediate Tree Nodes | Serotonins |
| Direct Parent | N-acylserotonins |
| Alternative Parents | Hydroxyindoles 3-alkylindoles Piperidinecarboxamides Piperidinones Delta lactams 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles 1,3-dicarbonyl compounds Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | N-acylserotonin - Hydroxyindole - 3-alkylindole - Indole - 3-piperidinecarboxamide - Piperidinecarboxamide - Delta-lactam - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Piperidinone - Piperidine - Benzenoid - 1,3-dicarbonyl compound - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Lactam - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as n-acylserotonins. These are aromatic heterocyclic compounds containing a serotonin, in which the amine group is acylated. |
| External Descriptors | Not available |
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 30.13, Max Conc. mM: 100 |
|---|---|
| Sensitivity | heat sensitive；Moisture sensitive |
| Molecular Weight | 301.340 g/mol |
| XLogP3 | 1.000 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 301.143 Da |
| Monoisotopic Mass | 301.143 Da |
| Topological Polar Surface Area | 94.200 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 429.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
