Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 ( TLR7/9 ) signaling .
| Isomeric SMILES | CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO |
|---|---|
| Molecular Weight | 335.9 |
| Reaxy-Rn | 253894 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=253894&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Kejie Wang, Bingye Shi, Yihui Chen, Chunyan Hou, Xie Li, Xiaoqiang Qiao, Tingting Wang. (2025) Synthesis of Perfluorooctyl-Functionalized Halloysite Nanotubes for Dispersive Solid-Phase Extraction of Antimalarial Inhibitors in Whole Blood. JOURNAL OF SEPARATION SCIENCE, 48 (7): (e70226). [PMID:40650450] [10.1002/jssc.70226] |
| 2. Yu Wang, Hongrui Fan, Qinjun Chen, Haolin Song, Xuwen Li, Boyu Su, Tao Sun, Leilei Cheng, Chen Jiang. (2025) Mitocytosis-inducing nanoparticles alleviate gemcitabine resistance via dual disruption of pyrimidine synthesis and redox homeostasis in pancreatic ductal adenocarcinoma. BIOMATERIALS, [PMID:40818322] [10.1016/j.biomaterials.2025.123630] |
| 3. Dai Yan, Sang Xiu-Bo, Bai Wen-Pei. (2023) N-acetylcysteine and Hydroxychloroquine Ameliorate ADMA-Induced Fetal Growth Restriction in Mice via Regulating Oxidative Stress and Autophagy. Reproductive Sciences, [PMID:37845590] [10.1007/s43032-023-01380-z] |
| 4. Mu Jiaxiang, Meng Zhaoxu, Liu Xinran, Guan Ping, Lian He. (2023) Implantable Nanofiber Membranes with Synergistic Photothermal and Autophagy Inhibition Effects for Enhanced Tumor Therapy Efficacy. Advanced Fiber Materials, [PMID:] [10.1007/s42765-023-00311-6] |
| 5. Lan-Yi Hu, Ye Yuan, Zi-Xuan Wen, Yi-Yue Hu, Miao-Miao Yin, Yan-Jun Hu. (2023) Affinity binding of COVID-19 drug candidates (chloroquine/hydroxychloroquine) and serum albumin: Based on photochemistry and molecular docking. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, [PMID:36753782] [10.1016/j.jphotobiol.2023.112667] |
| 6. Jingxiang Zhao, Zhiqiang Zhao, Wanting Hou, Yue Jiang, Guobin Liu, Xuelian Ren, Kun Liu, Hong Liu, Kaixian Chen, He Huang. (2022) Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine. MOLECULES, 27 (16): (5175). [PMID:36014414] [10.3390/molecules27165175] |
| 7. Zhang Man, Bai Yang, Xu Chang, Qi Yiying, Meng Jiahong, Zhang Wenkan, Su Hang, Yan Weiqi. (2021) Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma. Frontiers in Cell and Developmental Biology, [PMID:34414176] [10.3389/fcell.2021.650846] |
| 8. Rongliang Wang, Jiawei Li, Xingquan Xu, Jia Xu, Huiming Jiang, Zhongyang Lv, Rui Wu, Ziying Sun, Wenjie Guo, Yang Sun, Shiro Ikegawa, Qing Jiang, Dongquan Shi. (2021) Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model. Journal of Orthopaedic Translation, [PMID:34094861] [10.1016/j.jot.2021.05.001] |
| 9. Xingquan Xu, Rongliang Wang, Rui Wu, Wenjin Yan, Tianshu Shi, Qing Jiang, Dongquan Shi. (2020) Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation. FASEB JOURNAL, 34 (6): (8402-8415). [PMID:32367591] [10.1096/fj.201902528RRR] |
| 10. Chen Ping, Zhang Xueer, Fang Qiaomiao, Zhao Zhongxiang, Lin Chaozhan, Zhou Yuan, Liu Fangle, Zhu Chenchen, Wu Aizhi. (2024) Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo. Journal of Natural Medicines, [PMID:38403724] [10.1007/s11418-024-01782-6] |
| 11. Boqiang Gao, Haoge Liang, Jie Wang, Yan Huang, Jingzhen Wang, Jia Song, Pan Hu, Hu Yang, Shuanglong Ma. (2024) Efficient adsorption of hydroxychloroquine by carboxylated lignin-based sponge: Quantification of the adsorption contribution of interactions. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.129359] |
| 12. Zhipeng Zhang, Huizi Zheng, Ying Liu, Shuang Ma, Qi Feng, Jiao Qu, Xiaolin Zhu. (2024) Highly sensitive detection of multiple antiviral drugs using graphitized hydroxylated multi-walled carbon nanotubes/ionic liquids-based electrochemical sensors. ENVIRONMENTAL RESEARCH, [PMID:38354882] [10.1016/j.envres.2024.118466] |
| 13. Linming Li, Yan Chen, Ming Zhang, Suying Li, Shuaiqi Feng, Yan-Qin He, Ning Zhang, Zhifang Liu, Meifeng Liu, Qing-Peng Wang. (2024) Hydroxychloroquine Platinum(IV) Conjugate Displaying Potent Antimetastatic Activities by Suppressing Autophagy to Improve the Tumor Microenvironment. DALTON TRANSACTIONS, [PMID:39092626] [10.1039/D4DT01794C] |
| 14. Chen Yun-Ting, Han Jing-Wen, Yu Zi-Wei, Yang Ruo-Yu, Wu Mei-Juan, Huang Pin-Fang, Liu Meng-Meng. (2025) Smartphone-assisted portable immunosensor toward on-site detection of tumor necrosis factor-α inhibitor adalimumab for personalized treatment. MICROCHIMICA ACTA, 192 (6): (1-11). [PMID:40404886] [10.1007/s00604-025-07230-w] |
| 15. Xu Lian, Chen Jiangwei, Zhang Wenli, Du Qianying, Huang Xin, Luo Ying, Wang Yi, Chen Sijin, Rong Xiyue, Liu Jia, Xu Zhongsheng, Ran Haitao, Liu Yun, Guo Dajing, Xu Jie. (2025) A bismuth-based nanoplatform with synergistic fibrin/NET disruption and antioxidant/anti-inflammatory capabilities for enhanced thrombolysis and prevention of deep vein thrombosis recurrence. JOURNAL OF NANOBIOTECHNOLOGY, [PMID:41299690] [10.1186/s12951-025-03864-3] |
| 16. Qiu Yueping, Liu Yijie, Ding Haiying, Xin Wenxiu, Lu Shuanghui, Hu Yan, Chen Jing, Weng Qinjie, Wang Jiajia, Fang Luo. (2026) Osimertinib activates TFEB to trigger hepatocyte cytoplasmic vacuolation-associated cell death. Cell Communication and Signaling, [PMID:41612351] [10.1186/s12964-026-02688-4] |
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