Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Iron Chelator, Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.
Dp44mT (di-2-pyridylketone-4, 4, -dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndr
Storage
Protected from light, Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
This compound belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-member aromatic heterocycle which consists of one nitrogen atom and five carbon atoms.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
≥62.5 mg/mL in DMSO; insoluble in H2O; ≥22.95 mg/mL in EtOH
Sensitivity
ligh sensitive
Refractive Index
n20D1.64 (Predicted)
Boil Point(°C)
438.37° C at 760 mmHg (Predicted)
Melt Point(°C)
165.90° C (Predicted)
Molecular Weight
285.370 g/mol
XLogP3
2.200
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
285.105 Da
Monoisotopic Mass
285.105 Da
Topological Polar Surface Area
85.500 Ų
Heavy Atom Count
20
Formal Charge
0
Complexity
335.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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J2517764