Jatrorrhizine - analytical standard, ≥97%(HPLC) , CAS No.3621-38-3

CAS: 3621-38-3 Cat. No.: J101538 Molecular Weight: 355.38 EC Number: 222-817-3
AVAILABLE TO ORDER
GRADE & PURITY Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. ≥97%(HPLC)
Synonyms
FT-0686648 | jateorrhizine | Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy- (8CI) | Ethynyldimethylcarbinol | Trichloroethylsilicon | CHEBI:6087 | 2,2,2-Trichloro-1-ethanol | A-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium | NSC645313
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
J101538-5mg
3
$19.90
25mg
J101538-25mg
4
$70.90
100mg
J101538-100mg
1
$226.90
Enter a quantity for the sizes you want to add.
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Why this grade

analytical standard, ≥97%(HPLC) Analytical standard for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
FT-0686648 | jateorrhizine | Berbinium, 7, 8, 13, 13a-tetradehydro-3-hydroxy-2, 9, 10-trimethoxy- (8CI) | Ethynyldimethylcarbinol | Trichloroethylsilicon | CHEBI:6087 | 2, 2, 2-Trichloro-1-ethanol | A-Tetradehydro-3-hydroxy-2, 9, 10-trimethoxyberbinium | NSC645313
Specifications & Purity
analytical standard, ≥97%(HPLC)
Biochemical and Physiological Mechanisms
Novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb Rhizoma Coptidis. Protects neuronal-like cells against H 2 O 2 -induced toxicity. Protects against okadaic acid induced oxidative toxicity through inhibiting the Mitogen-acti
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Analytical standard
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥97%(HPLC)
Names and Identifiers
Canonical SmilesCOC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC
IUPAC Name2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
InChIKeyMXTLAHSTUOXGQF-UHFFFAOYSA-O
INCHI1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
Isomeric SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC
Molecular Weight 355.38
Reaxy-Rn 1555102
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1555102&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassAlkaloids and derivatives
ClassProtoberberine alkaloids and derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentProtoberberine alkaloids and derivatives
Alternative Parents Isoquinolines and derivatives  Anisoles  Alkyl aryl ethers  1-hydroxy-2-unsubstituted benzenoids  Pyridinium derivatives  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  Organic cations  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Protoberberine skeleton - Isoquinoline - Anisole - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Pyridinium - Pyridine - Heteroaromatic compound - Ether - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic cation - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
External Descriptors Isoquinoline alkaloids
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HaCaT (4069 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C2C12 (756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium sp. (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Large T antigen (1457 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATP-dependent molecular chaperone HSP82 (2186 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
vpr Aberrant vpr protein (14595 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
B2303445Certificate of AnalysisOct 30, 2025 J101538
B2604095Certificate of AnalysisMay 08, 2025 J101538
E2521394Certificate of AnalysisMay 08, 2025 J101538
E2521426Certificate of AnalysisMay 08, 2025 J101538
E2521427Certificate of AnalysisMay 08, 2025 J101538
E2629067Certificate of AnalysisMay 08, 2025 J101538
A2509243Certificate of AnalysisApr 13, 2024 J101538
A2509244Certificate of AnalysisApr 13, 2024 J101538
F2117162Certificate of AnalysisApr 02, 2024 J101538
B2303382Certificate of AnalysisNov 12, 2022 J101538
E2409035Certificate of AnalysisNov 12, 2022 J101538
J2327246Certificate of AnalysisNov 12, 2022 J101538

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Chemical and Physical Properties
Molecular Weight338.400 g/mol
XLogP33.400
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass338.139 Da
Monoisotopic Mass338.139 Da
Topological Polar Surface Area51.800 Ų
Heavy Atom Count25
Formal Charge1
Complexity461.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei.  (2023)  Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids.  MICROCHIMICA ACTA,  190  (12): (1-12).  [PMID:37999777] [10.1007/s00604-023-06053-x]
2. Longlong Gao, Rui Tian, Yong Shao.  (2023)  Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site.  Chemistry-Switzerland,  (3): (1497-1507).  [PMID:] [10.3390/chemistry5030102]
3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]
4. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang.  (2020)  The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance.  NEW JOURNAL OF CHEMISTRY,  44  (27): (11704-11709).  [PMID:] [10.1039/D0NJ01197E]
5. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou.  (2018)  Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study.  MOLECULES,  23  (4): (714).  [PMID:29561801] [10.3390/molecules23040714]
6. Wang Chenlu, Zhou Wei, Liao Xiaoyan, Zhang Wenpeng, Chen Zilin.  (2017)  An etched polyether ether ketone tube covered with immobilized graphene oxide for online solid phase microextraction of quaternary alkaloids prior to their quantitation by HPLC-MS/MS.  MICROCHIMICA ACTA,  184  (8): (2715-2721).  [PMID:] [10.1007/s00604-017-2262-8]
7. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao.  (2016)  Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter.  Chemistry-An Asian Journal,  11  (14): (2041-2048).  [PMID:27252050] [10.1002/asia.201600459]
8. Zixin Zhang, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:26141275] [10.1016/j.chroma.2015.06.031]
9. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao.  (2015)  Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification.  BIOSENSORS & BIOELECTRONICS,      [PMID:25950941] [10.1016/j.bios.2015.04.076]
10. Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma.  JOURNAL OF SEPARATION SCIENCE,  38  (12): (2117-2125).  [PMID:25832420] [10.1002/jssc.201500264]
11. Zhuo Ye, Yinfeng Li, Jianguo Wen, Kunjing Li, Baoxian Ye.  (2014)  Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode.  TALANTA,      [PMID:24881532] [10.1016/j.talanta.2014.03.026]
12. Lihong Liu, Zilin Chen.  (2012)  Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.  ANALYTICA CHIMICA ACTA,      [PMID:22769040] [10.1016/j.aca.2012.05.054]
13. Jing Zhu, Qing Hong Zhang, Wen Wu Wang.  (2024)  Pattern Recognition of Alkaloids by Inhibiting the Catalytic Activity of Dopzymes for Dopamine.  ANALYTICAL CHEMISTRY,      [PMID:39014901] [10.1021/acs.analchem.4c01920]
14. Liyun Ma, Simin Liu, Qing Wang, Lin Yao, Li Xu.  (2015)  Cucurbit(6)uril immobilized on silica: A novel high-performance liquid chromatographic stationary phase.  JOURNAL OF SEPARATION SCIENCE,  38  (7): (1082-1089).  [PMID:25641573] [10.1002/jssc.201401049]
15. Liyun Ma, Si-Min Liu, Lin Yao, Li Xu.  (2014)  Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25528071] [10.1016/j.chroma.2014.12.002]
16. Lilin Tang, Wenpeng Zhang, Haiyan Zhao, Zilin Chen.  (2015)  Tyrosinase inhibitor screening in traditional Chinese medicines by electrophoretically mediated microanalysis.  JOURNAL OF SEPARATION SCIENCE,  38  (16): (2887-2892).  [PMID:26037533] [10.1002/jssc.201500371]
17. Ting Liu, Jia Tang, Xinyi Lu, Lu Jiang, Rui Zhang, Miaoqing Zhang, Jingpu Zhang, Danqing Song, Dousheng Zhang, Mingzhe Xu.  (2025)  Ocular Toxicity and Mechanistic Investigation for Berberine and Its Metabolite Berberrubine on Zebrafish.  MOLECULES,  30  (23): (4602).  [PMID:41375198] [10.3390/molecules30234602]
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