KDOAM-25 citrate - 10mM in DMSO , CAS No.2448475-08-7

CAS: 2448475-08-7 Cat. No.: K656079 Molecular Weight: 499.51

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC 50 s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells

In Vitro

KDOAM-25 citrate inhibits most potently KDM5B with an IC 50 of ～50 μM and the other KDM5 family members at concentrations above 100 μM. KDOAM-25 citrate shows no cellular activity on any of the other tested JmjC family members. ?\nKDOAM-25 citrate is able to reduce the viability of MM1S cells with an IC 50 of ～30 μM after a delay of 5-7 days. ?\nKDOAM-25 citrate treatment results in a G1 cell-cycle arrest with an increased proportion of MM1S in G1 and a decrease of the proportion of cells in G2 without an increase in the proportion of cells in the apoptotic sub-G1 phase. ?\nKDOAM-25 citrate (50 μM) increases with approximately twice as much H3K4me3 in in multiple myeloma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:KDM5

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC 50 s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional

Storage

Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 499.51