Ketotifen Fumarate - 10mM in DMSO , Histamine H1 receptor antagonist, CAS No.34580-14-8, Histamine H1 receptor antagonist

CAS: 34580-14-8 Cat. No.: K408699 Molecular Weight: 425.5 EC Number: 252-100-0
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Synonyms
4,​9-​dihydro-​4-​(1-​methyl-​4-​piperidinylidene)​-10H-​benzo[4,​5]​cyclohepta[1,​2-​b]​thiophen-​10-​one,(2E)​-​2-​butenedioate (1:1)
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1ml
K408699-1ml
1

$114.90

$166.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Ketotifen Fumarate is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Synonyms
4, ​9-​dihydro-​4-​(1-​methyl-​4-​piperidinylidene)​-10H-​benzo[4, ​5]​cyclohepta[1, ​2-​b]​thiophen-​10-​one, (2E)​-​2-​butenedioate (1:1)
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Ketotifen Fumarate is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Mechanism of action
Histamine H1 receptor antagonist
Names and Identifiers
Isomeric SMILES CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=C/C(=O)O)\C(=O)O
WGK Germany 3
RTECS DE8260000
Molecular Weight 425.5
Reaxy-Rn 40483148
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=40483148&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
HRH1 Tclin Histamine H1 receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySolubility (25°C) In vitro      
Melt Point(°C)192°C
Citations of This Product
References
1. Mingkang Zhang, Jinru Yang, Yufan Yuan, Yan Zhou, Yazhi Wang, Ruirui Cui, Yimai Maliu, Fen Xu, Xin’an Wu.  (2024)  Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride-induced liver injury.  MOLECULAR IMMUNOLOGY,      [PMID:38626622] [10.1016/j.molimm.2024.04.009]
Solution Calculators
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