L-Glutamic acid γ-monohydroxamate - Moligand™, ≥97% , CAS No.1955-67-5

CAS: 1955-67-5 Cat. No.: L302676 Molecular Weight: 162.14

GRADE & PURITY Moligand™, ≥97%

Synonyms

BDBM50129196 | Q27093441 | L-Glutamic | Glutamate-gamma-hydroxamate | L-Glutamine, N-hydroxy- | SCHEMBL4321249 | glutamine hydroxamate | gamma-glutamylhydroxylamine | L-gamma-Glutamyl hydroxamate | Nifuradene (USAN/INN) | Glutamyl-gamma-hydroxamate | A-m

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

BDBM50129196 | Q27093441 | L-Glutamic | Glutamate-gamma-hydroxamate | L-Glutamine, N-hydroxy- | SCHEMBL4321249 | glutamine hydroxamate | gamma-glutamylhydroxylamine | L-gamma-Glutamyl hydroxamate | Nifuradene (USAN/INN) | Glutamyl-gamma-hydroxamate | A-m

Specifications & Purity

Moligand™, ≥97%

Biochemical and Physiological Mechanisms

It can be used as vanadium ligand to enhance vanadium metabolic activity. L-Glu (γ) HXM is also used as a substrate for E. coli L-Asparagine synthase B and as an irreversible inhibitor of ATP-dependent e. coli γ-glutamylcysteine synthetase.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥97%

Names and Identifiers

• Canonical Smiles: C(CC(=O)NO)C(C(=O)O)N
• IUPAC Name: (2S)-2-amino-5-(hydroxyamino)-5-oxopentanoic acid
• InChIKey: YVGZXTQJQNXIAU-VKHMYHEASA-N
• INCHI: 1S/C5H10N2O4/c6-3(5(9)10)1-2-4(8)7-11/h3,11H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• Isomeric SMILES: C(CC(=O)NO)[C@@H](C(=O)O)N
• Molecular Weight: 162.14
• Reaxy-Rn: 2362759
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2362759&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Glutamine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Glutamine and derivatives
• Alternative Parents: L-alpha-amino acids Fatty acids and conjugates Hydroxamic acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Glutamine or derivatives - Alpha-amino acid - L-alpha-amino acid - Fatty acid - Hydroxamic acid - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Organic nitrogen compound - Organic oxide - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as glutamine and derivatives. These are compounds containing glutamine or a derivative thereof resulting from reaction of glutamine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: hydroxamic acid - glutamic acid derivative

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

FOLH1 Tclin Glutamate carboxypeptidase II (711 Activities)

Discover Target: FOLH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSK Tchem Tyrosine-protein kinase CSK (2395 Activities)

Discover Target: CSK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 162.140 g/mol
• XLogP3: -4.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 162.064 Da
• Monoisotopic Mass: 162.064 Da
• Topological Polar Surface Area: 113.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 159.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1