Lck inhibitor 2 - 10mM in DMSO , CAS No.944795-06-6

CAS: 944795-06-6 Cat. No.: L655521 Molecular Weight: 335.36 PubChem CID: 25138012

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk , Lyn, Btk and Txk respectivelyIC50 Value: 13 nM(Lck) Target: Src family kinaseLck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM).

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK , BTK , LYN, SYK , and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck , Btk , Lyn, Btk and Txk respectively \nIC50 Value: 13 nM(Lck) \nTarget: Src fam

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=C(C=C(C=C1)O)NC2=NC(=NC=C2)NC3=CC=CC(=C3)C(=O)N
• PubChem CID: 25138012
• Molecular Weight: 335.36