Short transient receptor potential channel 6 (TRPC6)

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  1. GSK 2193874, Channel blocker of TRPV4
    CAS: 1336960-13-4 EC Number: 808-437-6 Formula: C37H38BrF3N4O Molecular Weight: 691.62
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: G287297
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    IUPAC Name
    7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
    SMILES
    C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7
    InChIKey
    UIVOZBSCHXCGPS-UHFFFAOYSA-N
    InChI
    1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36show more
    Synonyms
    GSK2193874 | GSK-2193874 | GTPL6465 | NCGC00370767-01 | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopr...
  2. GFB-8438, Channel blocker of TRPC5
    CAS: 2304549-73-1 Formula: C16H14ClF3N4O2 Molecular Weight: 386.76
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: G422733
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    IUPAC Name
    5-chloro-4-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1H-pyridazin-6-one
    SMILES
    C1CN(C(=O)CN1C2=C(C(=O)NN=C2)Cl)CC3=CC=CC=C3C(F)(F)F
    InChIKey
    MITRKIWBJVJRAM-UHFFFAOYSA-N
    InChI
    1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26)
    Synonyms
    3(2H)​-​Pyridazinone,4-​chloro-​5-​[3-​oxo-​4-​[[2-​(trifluoromethyl)​phenyl]​methyl]​-​1-​piperazinyl]​-
  3. GFB-8438, Channel blocker of TRPC5
    CAS: 2304549-73-1 Formula: C16H14ClF3N4O2 Molecular Weight: 386.76
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: G412526
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    IUPAC Name
    5-chloro-4-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1H-pyridazin-6-one
    SMILES
    C1CN(C(=O)CN1C2=C(C(=O)NN=C2)Cl)CC3=CC=CC=C3C(F)(F)F
    InChIKey
    MITRKIWBJVJRAM-UHFFFAOYSA-N
    InChI
    1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26)
    Synonyms
    3(2H)​-​Pyridazinone,4-​chloro-​5-​[3-​oxo-​4-​[[2-​(trifluoromethyl)​phenyl]​methyl]​-​1-​piperazinyl]​-
  4. GSK 2193874, Channel blocker of TRPV4
    CAS: 1336960-13-4 EC Number: 808-437-6 Formula: C37H38BrF3N4O Molecular Weight: 691.62
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: G421274
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    Technical Identifiers
    IUPAC Name
    7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
    SMILES
    C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7
    InChIKey
    UIVOZBSCHXCGPS-UHFFFAOYSA-N
    InChI
    1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36show more
    Synonyms
    GSK2193874 | GSK-2193874 | GTPL6465 | NCGC00370767-01 | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopr...
  5. HELSS, Channel blocker of TRPC5
    CAS: 88070-98-8 EC Number: 635-829-2 Formula: C16H13BrO2 Molecular Weight: 317.2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    Out of Stock Item #: H274892
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    IUPAC Name
    (6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
    SMILES
    C1CC(=CBr)OC(=O)C1C2=CC=CC3=CC=CC=C32
    InChIKey
    BYUCSFWXCMTYOI-ZRDIBKRKSA-N
    InChI
    1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+
    Synonyms
    SR-01000075707-1 | 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one | HMS3649C04 | 4-Monochlorodiphenyl...
  6. SAR7334, Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7
    CAS: 1333210-07-3 PubChem CID: 53378752 Formula: C21H22ClN3O Molecular Weight: 367.87
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    In Stock Item #: S413561
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    IUPAC Name
    4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile
    SMILES
    C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N
    InChIKey
    RLKRLNQEXBPQGQ-OZOXKJRCSA-N
    InChI
    1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-show more
    Synonyms
    Benzonitrile | 4-​[[(1R,​2R)​-​2-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​2,​3-​dihydro-​1H-​inden-​1-​yl]​oxy]​-​3-​chlo...
  7. SAR7334, Channel blocker of TRPC3;Channel blocker of TRPC6;Channel blocker of TRPC7
    CAS: 1333210-07-3 PubChem CID: 53378752 Formula: C21H22ClN3O Molecular Weight: 367.87
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: S421260
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    Technical Identifiers
    IUPAC Name
    4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile
    SMILES
    C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N
    InChIKey
    RLKRLNQEXBPQGQ-OZOXKJRCSA-N
    InChI
    1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-show more
    Synonyms
    Benzonitrile | 4-​[[(1R,​2R)​-​2-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​2,​3-​dihydro-​1H-​inden-​1-​yl]​oxy]​-​3-​chlo...
  8. TRPC3/6-IN-1
    CAS: 736945-96-3 PubChem CID: 1096735
    Out of Stock Item #: T1438110
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    IUPAC Name
    3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
    SMILES
    COC1=CC=C(C=C1)NC2=NC(=CS2)C(=O)N3CCC4=CC=CC=C4C3
    InChIKey
    NTXBDULODNTCKP-UHFFFAOYSA-N
    InChI
    1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
  9. Bromoenol lactone
    CAS: 88070-98-8 EC Number: 635-829-2 Formula: C16H13BrO2 Molecular Weight: 317.2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    Out of Stock Item #: B1493935
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  10. TRPC6-IN-3
    CAS: 2311863-36-0 EC Number: 889-792-4 PubChem CID: 138674835 Formula: C22H22FN5O3 Molecular Weight: 423.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    Out of Stock Item #: T1497434
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