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Nt-3 growth factor receptor (NTRK3)

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  1. LarotrectinibFor, Inhibitor of neurotrophic receptor tyrosine kinase 1
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    LarotrectinibFor, Inhibitor of neurotrophic receptor tyrosine kinase 1
    CAS: 1223403-58-4 EC Number: 826-190-2 Formula: C21H22F2N6O2 Molecular Weight: 428.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    In Stock Item #: L172696
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    IUPAC Name
    (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
    SMILES
    C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F
    InChIKey
    NYNZQNWKBKUAII-KBXCAEBGSA-N
    InChI
    1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12show more
    Synonyms
    NYNZQNWKBKUAII-KBXCAEBGSA-N | DB14723 | Q27081513 | ARRY470 | ARRY-470 | ARRY-470; larotrectinib | AS-35231 | Larotre...
  2. GNF 5837, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3;Inhibitor of lanosterol synthase
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    GNF 5837, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3;Inhibitor of lanosterol synthase
    CAS: 1033769-28-6 EC Number: 806-102-9 Formula: C28H21F4N5O2 Molecular Weight: 535.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    In Stock Item #: G287150
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    IUPAC Name
    1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea
    SMILES
    CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)C(=CC5=CC=CN5)C(=O)N4
    InChIKey
    YYDUWLSETXNJJT-MTJSOVHGSA-N
    InChI
    1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-3show more
    Synonyms
    1033769-28-6 | BDBM50384727 | YYDUWLSETXNJJT-MTJSOVHGSA-N | A896483 | Q27077827 | (Z)-1-(3-((3-((1H-pyrrol-2-yl)methy...
  3. SU5416
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    SU5416
    CAS: 204005-46-9 EC Number: 621-120-5 Formula: C15H14N2O Molecular Weight: 238.28
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    In Stock Item #: S125835
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    IUPAC Name
    (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
    SMILES
    CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
    InChIKey
    WUWDLXZGHZSWQZ-WQLSENKSSA-N
    InChI
    1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
    Synonyms
    (Z)-Semaxinib | BRN 0844684 | CAS-204005-46-9 | NCGC00094381-01 | SCHEMBL194769 | SCHEMBL19571 | SU005416 | Lopac0_00...
  4. GW2580, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
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    GW2580, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
    CAS: 870483-87-7 EC Number: 809-788-8 Formula: C20H22N4O3 Molecular Weight: 366.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: G129822
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    IUPAC Name
    5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
    SMILES
    COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
    InChIKey
    MYQAUKPBNJWPIE-UHFFFAOYSA-N
    InChI
    1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
    Synonyms
    GW-2580 | 5-({3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl}methyl)pyrimidine-2,4-diamine | EN300-08618 | SCHEMBL43265...
  5. Entrectinib, ALK tyrosine kinase receptor inhibitor
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    Entrectinib, ALK tyrosine kinase receptor inhibitor
    CAS: 1108743-60-7 EC Number: 816-298-8 Formula: C31H34F2N6O2 Molecular Weight: 560.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: E302199
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    IUPAC Name
    N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide
    SMILES
    CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
    InChIKey
    HAYYBYPASCDWEQ-UHFFFAOYSA-N
    InChI
    1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/hshow more
    Synonyms
    DB11986 | RXDX 101 | ENTRECTINIB [WHO-DD] | RG 6268 | NCGC00484067-01 | NCGC00484067-02 | NSC774769 | NSC-774769 | N-...
  6. Altiratinib, Neurotrophic tyrosine kinase receptor inhibitor
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    Altiratinib, Neurotrophic tyrosine kinase receptor inhibitor
    CAS: 1345847-93-9 Formula: C26H21F3N4O4 Molecular Weight: 510.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: A421300
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    IUPAC Name
    1-N'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES
    C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F
    InChIKey
    GNNDEPIMDAZHRQ-UHFFFAOYSA-N
    InChI
    1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,show more
    Synonyms
    NSC784590 | NSC-784590 | DCC-270 | J-690136 | Q27074416 | Altiratinib(DCC-2701) | s6412 | GNNDEPIMDAZHRQ-UHFFFAOYSA-N...
  7. Altiratinib, Neurotrophic tyrosine kinase receptor inhibitor
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    Altiratinib, Neurotrophic tyrosine kinase receptor inhibitor
    CAS: 1345847-93-9 Formula: C26H21F3N4O4 Molecular Weight: 510.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: A413439
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    IUPAC Name
    1-N'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES
    C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F
    InChIKey
    GNNDEPIMDAZHRQ-UHFFFAOYSA-N
    InChI
    1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,show more
    Synonyms
    NSC784590 | NSC-784590 | DCC-270 | J-690136 | Q27074416 | Altiratinib(DCC-2701) | s6412 | GNNDEPIMDAZHRQ-UHFFFAOYSA-N...
  8. BPR1K871 - Moligand™, ≥97% CAS No(2443767-35-7) by Aladdin Scientific
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    BPR1K871 (DBPR114)
    CAS: 2443767-35-7 Formula: C25H28ClN7O2S Molecular Weight: 526.1
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    Out of Stock Item #: B412579
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    IUPAC Name
    1-(3-chlorophenyl)-3-[5-[2-[[7-[3-(dimethylamino)propoxy]quinazolin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
    SMILES
    CN(C)CCCOC1=CC2=C(C=C1)C(=NC=N2)NCCC3=CN=C(S3)NC(=O)NC4=CC(=CC=C4)Cl
    InChIKey
    MMVLETOTGHDVPQ-UHFFFAOYSA-N
    InChI
    1S/C25H28ClN7O2S/c1-33(2)11-4-12-35-19-7-8-21-22(14-19)29-16-30-23(21)27-10-9-20-15-28-25(36-20)32-24(34)31-18-6-3-5-17(26)13-18/h3,5-8,13-16H,4,9-12Hshow more
    Synonyms
    DBPR114 | 1-(3-Chlorophenyl)-3-(5-(2-((7-(3-(dimethylamino)propoxy)quinazolin-4-yl)amino)ethyl)thiazol-2-yl)urea
  9. CH7057288, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
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    CH7057288, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
    CAS: 2095616-82-1 Formula: C32H31N3O5S Molecular Weight: 569.67
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: C414182
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    IUPAC Name
    N-tert-butyl-2-[2-[8-(methanesulfonamido)-6,6-dimethyl-11-oxonaphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methylpyridine-4-carboxamide
    SMILES
    CC1=CC(=CC(=N1)C#CC2=CC3=C(C=C2)C4=C(O3)C(C5=C(C4=O)C=CC(=C5)NS(=O)(=O)C)(C)C)C(=O)NC(C)(C)C
    InChIKey
    DCGOHGQJHJXBGW-UHFFFAOYSA-N
    InChI
    1S/C32H31N3O5S/c1-18-14-20(30(37)34-31(2,3)4)16-21(33-18)10-8-19-9-12-24-26(15-19)40-29-27(24)28(36)23-13-11-22(35-41(7,38)39)17-25(23)32(29,5)6/h9,11show more
    Synonyms
    4-​Pyridinecarboxamide,2-​[2-​[6,​11-​dihydro-​6,​6-​dimethyl-​8-​[(methylsulfonyl)​amino]​-​11-​oxobenzo[b]​naphtho[2,...
  10. CH7057288, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
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    CH7057288, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3
    CAS: 2095616-82-1 Formula: C32H31N3O5S Molecular Weight: 569.67
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: C422540
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    Technical Identifiers
    IUPAC Name
    N-tert-butyl-2-[2-[8-(methanesulfonamido)-6,6-dimethyl-11-oxonaphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methylpyridine-4-carboxamide
    SMILES
    CC1=CC(=CC(=N1)C#CC2=CC3=C(C=C2)C4=C(O3)C(C5=C(C4=O)C=CC(=C5)NS(=O)(=O)C)(C)C)C(=O)NC(C)(C)C
    InChIKey
    DCGOHGQJHJXBGW-UHFFFAOYSA-N
    InChI
    1S/C32H31N3O5S/c1-18-14-20(30(37)34-31(2,3)4)16-21(33-18)10-8-19-9-12-24-26(15-19)40-29-27(24)28(36)23-13-11-22(35-41(7,38)39)17-25(23)32(29,5)6/h9,11show more
    Synonyms
    4-​Pyridinecarboxamide,2-​[2-​[6,​11-​dihydro-​6,​6-​dimethyl-​8-​[(methylsulfonyl)​amino]​-​11-​oxobenzo[b]​naphtho[2,...
  11. Entrectinib (RXDX-101), ALK tyrosine kinase receptor inhibitor
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    Entrectinib (RXDX-101), ALK tyrosine kinase receptor inhibitor
    CAS: 1108743-60-7 EC Number: 816-298-8 Formula: C31H34F2N6O2 Molecular Weight: 560.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: E407778
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    Synonyms
    NMS-E628 | N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)ben...
  12. GNF 5837, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3;Inhibitor of lanosterol synthase
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    GNF 5837, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of neurotrophic receptor tyrosine kinase 2;Inhibitor of neurotrophic receptor tyrosine kinase 3;Inhibitor of lanosterol synthase
    CAS: 1033769-28-6 EC Number: 806-102-9 Formula: C28H21F4N5O2 Molecular Weight: 535.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: G420417
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    Technical Identifiers
    IUPAC Name
    1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea
    SMILES
    CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)C(=CC5=CC=CN5)C(=O)N4
    InChIKey
    YYDUWLSETXNJJT-MTJSOVHGSA-N
    InChI
    1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-3show more
    Synonyms
    1033769-28-6 | BDBM50384727 | YYDUWLSETXNJJT-MTJSOVHGSA-N | A896483 | Q27077827 | (Z)-1-(3-((3-((1H-pyrrol-2-yl)methy...
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